Postoperative Complications
Conditions
Brief summary
The aim of the study is to identify the correlation between ischaemia reperfusion injury and postoperative multiorgan damage during cardiopulmonary cardiac surgery; and to investigate biomarkers that can predict postoperative organ damage in cardiac surgery.
Detailed description
This study proposes to observe multi-organ functional impairment of the heart, kidney and brain after extracorporeal circulation in a prospective study of clinical patients; to obtain markers with diagnostic and predictive efficacy by collecting pre and postoperative serum and heart and ear tissue samples from patients with postoperative organ functional impairment, performing combined proteomic and metabolomic analyses, and by analysing them with detailed postoperative clinical prognostic data using machine learning algorithms.
Interventions
PROCEDUREischemic reperfusion injury
ischemic reperfusion injury is a pathological process in which the ischemic myocardium is restored to normal perfusion, but the tissue damage is progressively aggravated when the coronary artery supply is completely blocked after cardiopulmonary bypass surgery and then recanalised at a certain time.
Sponsors
Second Affiliated Hospital of Third Military Medical University
The Second Affiliated Hospital of Chongqing Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Age ≥50 years; patients requiring mitral valve replacement surgery or mitral valve plus aortic valve replacement under cardiopulmonary bypass 2. Agreed to participate in this study, and signed the informed consent form.
Exclusion criteria
1. History of neurological disease (stroke, reversible ischemic hypoxia, transient ischemic attack, or Neurodegeneration) ; 2. Patients with severe preoperative renal insufficiency (serum creatinine \> 442 μmol/L or need renal replacement therapy) , 3. liver dysfunction (Child-Pugh grade C) 4. myocardial infarction within 4 weeks 5. ASA grade ≥ V
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| incidence of postoperative cardiac injury | from the ending of surgery to 7 days after surgery | troponin I will be tested before and after surgery |
| incidence of postoperative acute kidney injury | from the ending of surgery to 7 days after surgery | renal function will be tested before and after surgery |
| incidence of postoperative brain injury | from the ending of surgery to 7 days after surgery | deliriumwill be tested before and after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of postoperative arrhythmia events | from the ending of surgery to 72 hours after surgery | postoperative arrhythmia events are recorded according to follow-up visits after surgery |
Countries
China
Contacts
Primary ContactQiao Guo, MD
Backup ContactDagang Wang, MD
Outcome results
None listed