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Causes of Mortality in Kidney Transplant Recipients

Causes of Mortality in Kidney Transplant Recipients, a Paradigm Shift

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05529186
Acronym
Paradigme
Enrollment
7000
Registered
2022-09-06
Start date
2022-03-14
Completion date
2023-12-14
Last updated
2023-11-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal Disease

Keywords

renal disease, kidney transplant

Brief summary

The causes of mortality in kidney transplant patients and the risk factors for mortality have been widely published. However, there is a high variability according to geographical areas and time. Recent studies suggest that the classical hierarchy of causes of mortality, i.e. the predominance of cardiovascular causes of death, could be overturned by the increase in infectious and cancer-related deaths. Investigators will try to highlight this paradigm shift and the related risk factors by studying two large French transplantation databases.

Interventions

None listed

Sponsors

University Hospital, Strasbourg, France
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum

Inclusion criteria

* Adult subject (≥18 years old) during transplantation * Transplantation performed between 01/01/2008 and 31/12/2014 * Kidney transplant subject, double transplants kidney + pancreas, or kidney + islets of Langherans * Subject previously transplanted other organs * Subject not objecting, after being informed, to the reuse of their data for the purposes of this research

Exclusion criteria

* Subject who expressed their opposition to participating in the study * Subject having received a double transplant during the same operation: kidney + heart, kidney + liver, kidney + lungs

Design outcomes

Primary

MeasureTime frame
Distribution of the causes of death of kidney transplant recipients presented in the form of percentageSix months of starting dialysis

Countries

France

Contacts

Primary ContactSophie CAILLARD, MD, PhD
sophie.caillard@chru-strasbourg.fr33 3 69 55 51 20

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026