High Flow Nasal Cannula vs Noninvasive Ventilation in Patients With Hypoxic Respiratory Failure Following Blunt Chest Trauma

High Flow Nasal Cannula vs Noninvasive Ventilation in Patients With Hypoxic Respiratory Failure Following Blunt Chest Trauma, a Randomized Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05527431

Enrollment

120

Registered

2022-09-02

Start date

2022-08-01

Completion date

2024-04-01

Last updated

2024-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blunt Injury of Thorax

Brief summary

to compare high flow nasal cannula against noninvasive ventilation in patients with non-sever blunt chest trauma in improvement of oxygenation, need for intubation and mechanical ventilation within 28 days

Interventions

DEVICEhigh flow nasal cannula

high flow nasal cannula

DEVICEnoninvasive ventilation

noninvasive ventilation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Age ≥18 y, * Willing and able to provide written informed consent prior to performing study procedures, * currently hospitalized and requiring medical care for non-sever blunt chest trauma (abbreviated injury severity scale ≤ 2) SpO2 90% or less while breathing 10 L/min.

Exclusion criteria

* Contraindications of noninvasive ventilation (face trauma or surgery, airway obstruction, upper gastrointestinal tract bleeding, disturbed level of consciousness), -smoker * intubation for any cause other than respiratory cause

Design outcomes

Primary

Measure	Time frame	Description
PaO2/FiO2 ratio	3 successive days	mean value of three successive PaO2/FiO2 ratio in mmHg between both groups

Secondary

Measure	Time frame	Description
Discomfort score	3 successive days	Discomfort related to oxygen delivery devices will be evaluated using a 10- point numeric scale which low number is low discomfort.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026