α-synucleinopathy
Conditions
Brief summary
α-Synucleinopathy is a cluster of neurodegenerative disease with motor and non-motor symptom. The data to be collected is intended to help healthcare providers make important medical decisions concerning α-synucleinopathy, through an enhanced understanding of the natural history, progression and multi-omics datasets of α-synucleinopathy.
Detailed description
α-Synucleinopathy is a cluster of neurodegenerative disease with motor and non-motor symptom, including Parkinson's disease (PD), multiple system atrophy (MSA) and dementia with lewy bodies (DLB). The data to be collected is intended to help healthcare providers make important medical decisions concerning α-synucleinopathy, through an enhanced understanding of the natural history, progression and multi-omics datasets of α-synucleinopathy. Datas will be accumulated retrospectively at research entry and prospectively during follow up.
Interventions
OTHERData collection
Neuropsychological assessment, brain MRI, electroencephalogram and biomarker datas will be collected
Sponsors
Fujian Medical University Union Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Participants with a clinical diagnosis of primary α-synucleinopathy * Unrelated healthy controls
Exclusion criteria
* Patients with secondary α-synucleinopathy that cannot be excluded. * Patients with other neurological disorders. * Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| UPDRS /UMSARS scores | Baseline | Disease severity was evaluated by the neurologist using the united Parkinson's disease rating scale (UPDRS) or united multiple system atrophy rating scale (UMSARS) separately as diagnosed. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| H&Y stage | Baseline | The Hoehn and Yahr （H&Y) |
| MoCA scores | Baseline | The Montreal Cognitive Assessment (MoCA) |
| Mean arterial pressure after 3 minutes of upright posture versus decubitus position (mmHg) | Baseline | Mean arterial pressure was calculated as ⅓ pulse pressure + diastolic pressure. |
| ACE-III scores | Baseline | Addenbrooke's Cognitive Examination (ACE) score |
| Plasma α-synuclein levels (ng/ml) | Baseline | — |
| Vic | Baseline | The intra-cellular compartment (Vic) of the Neurite Orientation Dispersion and Density Imaging (NODDI) model represents diffusion within the axons and cells. |
| PAF (Hz) | Baseline | The alpha-peak frequency (PAF) is the frequency with the highest power within the alpha-band. |
| HRV (ms) | Baseline | Heart rate variability (HRV) was calculated as the maximum bpm - minimum bpm. |
Countries
China
Contacts
Primary ContactXiaodong Pan
Outcome results
None listed