Depression, Diabetes Mellitus
Conditions
Keywords
Brain Derived Neurotrophic Factor, Diabetes Mellitus
Brief summary
This study aimed to evaluate the relation between the levels of (Brain Derived Neurotropic Factor) BDNF and val66met polymorphism of BDNF gene, and the presence of depression in type 2 diabetes. In addition to studying the relationship between BDNF level and val66met polymorphism of its gene and assessing relation between BDNF level and obesity.
Detailed description
The study included 88 type 2 diabetic patients, which are further divided into two groups; depressed and non-depressed. Depression was assessed by Hamilton Depression Rating Scale (HAM-D) and structured clinical interview for DSM-IV Axis disorder (SCID-I) for diagnosing depression and exclusion of other psychiatric disorders. Genotyping was performed by using Real Time-PCR (TaqMan probes).
Interventions
OTHERQuestionare
Assessing the presence or the absence of depression: By structured clinical interview for DSM-IV Axis disorder (SCID-I) and Hamilton Depression Rating Scale (HAM-D) for diagnosing depression and exclusion of other psychiatric disorders.
Sponsors
Kasr El Aini Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Adult patients who have type two diabetes with or without depression.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| BDNF level in blood | 1 day (At the time of recruitment) | Measurement of the level of BDNF in blood |
| val66met polymorphism of BDNF gene | 1 day (At the time of recruitment) | Measurement of val66met polymorphism of BDNF gene |
Countries
Egypt
Outcome results
None listed