Cardiac Surgery, Cardiopulmonary Bypass, Congenital Heart Disease, Fibrinogenemia
Conditions
Brief summary
Fibrinogen plays an important role in the coagulation cascade. Low levels of preoperative fibrinogen have been associated in adults with higher blood and transfusion requirements during surgery. Guidelines from the European Society of Anesthesiology and Intensive Care recommends fibrinogen substitution based on viscoelastic tests in adult cardiac surgery. Cardiopulmonary bypass results in a profound hemodilution and dilution of all coagulation factors. This is especially true in children where the priming volume of the cardiopulmonary bypass circuit is much higher compared to the patient's weight than in adults. Cardiopulmonary bypass generates high levels of tissue plasminogen activator resulting in a hyperfibrinolysis, further lowering fibrinogen levels. The aim of this retrospective study is to explore a possible relationship between preoperative fibrinogen levels and perioperative blood loss, as well as transfusion requirements in children undergoing cardiac surgery.
Interventions
PROCEDURECongenital cardiac surgery
All children who underwent congenital cardiac surgery with cardiopulmonary bypass between 2008 and 2018
Sponsors
Brugmann University Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 16 Years
Healthy volunteers
No
Inclusion criteria
* all children with cardiac surgery under cardiopulmonary bypass between 2008 and 2018 * Age \< 16 year
Exclusion criteria
* preoperative coagulopathy * Jehovah's witnesses * patients with fresh frozen plasma in the priming of the cardiopulmonary bypass circuit
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood loss | Day 0 | Blood loss in mL during surgery and postoperatively during the first 24h (day 0) will be extracted from our database |
| Transfusion requirements | Day 0 | Transfusion requirements of packed red cells ( in mL), fresh frozen plasma (in mL) and platelets (in mL) during the first 24h (day 0) will be extracted from our database |
Countries
Belgium
Outcome results
None listed