Neurodegenerative Disorder
Conditions
Brief summary
Cognitive impairment often appears in neurodegenerative diseases, and it is expected to further study the mechanism of sleep disorders associated with the progression of neurodegenerative diseases by exploring the clinical manifestations, imaging, and biological marker changes of sleep disorders in neurodegenerative diseases.
Interventions
OTHERData collection
Neuropsychological assessment, brain MRI, electroencephalogram and biomarker datas will be collected
Sponsors
Fujian Medical University Union Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Inclusion criteria
1. clinical diagnosis of neurodegenerative disease. 2. patients experience insomnia, excessive drowsiness, or confusion at night. 3. Patients experience frequent awakenings, daily sleep episodes, or nocturnal confusion. 4. The presence of one or more of the following characteristics: a. wandering at night with inappropriate activity; b. agitation, combativeness; c. confusion, disorientation, or marked delirium. 5. Polysomnographic monitoring showed the following two conditions: a. poor sleep efficiency, increased number and duration of awakenings; b. multiple sleep latency tests showed increased daytime sleepiness. 6. Presence of other medical symptoms that do not indicate the primary disease. 7. Other sleep disorders (e.g., periodic limb movement disorders, obstructive sleep apnea syndrome) may be present, but do not explain the patient 's main symptoms. 8. any of the above can be diagnosed
Exclusion criteria
1. Patients with other neurological disorders. 2. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PSQI Scores | Baseline | Pittsburgh Sleep Quality Index (PSQI), |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plasma Aβ-42 levels (ng/ml) | Baseline | — |
| MoCA scores | Baseline | The Montreal Cognitive Assessment (MoCA) |
| HRV (ms) | Baseline | Heart rate variability (HRV) was calculated as the maximum bpm - minimum bpm. |
| Vic | Baseline | The intra-cellular compartment (Vic) of the Neurite Orientation Dispersion and Density Imaging (NODDI) model represents diffusion within the axons and cells. |
| PAF (Hz) | Baseline | The alpha-peak frequency (PAF) is the frequency with the highest power within the alpha-band. |
| ACE-III scores | Baseline | Addenbrooke's Cognitive Examination (ACE) score |
Countries
China
Contacts
Primary ContactXiaodong Pan, Doctor
Outcome results
None listed