Concentrated Growth Factor Versus Platelet Rich Fibrin in Revitalization of Necrotic Young Permanent Incisors

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05522270

Enrollment

Registered

2022-08-31

Start date

2022-09-01

Completion date

2023-07-01

Last updated

2022-08-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Necrotic Pulp

Brief summary

Regenerative endodontic procedures (REPs) are the most recent proposal to manage immature permanent teeth with necrotic pulps. So in this study, the investigator will evaluate the clinical and radiographical revitalization success in necrotic young permanent anterior teeth of participants by using Concentrated Growth Factor versus Platelet-Rich Fibrin

Detailed description

has been entered

Interventions

PROCEDURErevitalization by concentrated growth factor

modified platelet concentrate

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Masking description

double (participant,outcomes Assessor)

Intervention model description

parallel assignment

Eligibility

Sex/Gender

ALL

Age

6 Years to 11 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy patients with immature permanent incisors * Presence of clinical signs and symptoms of necrosis or chronic apical periodontitis. The chronic apical periodontitis signs and symptoms include little discomfort with intermittent episodes of pus discharge through the sinus tract.

Exclusion criteria

1\. Abnormal tooth mobility. * Positive history of allergic reaction, systemic diseases, severe emotional or behavioral problems. * Unrestorable teeth * Abnormal tooth mobility * Children with systemic, severe behavioral, or emotional problems

Design outcomes

Primary

Measure	Time frame	Description
Clinical success rate	one year	Regaining tooth vitality with electric pulp testing Clinical examination includes pain absence, normal tooth mobility, and no sensitivity to percussion
Radiographic success using Periapical index (PAI)	one year	Criteria of PAI scores: score 1 normal periapical structure score 2 small changes in bone structures score 3 changes in bone structure with some mineral loss score 4 periodontitis with well-defined radiolucent area score 5 severe periodontitis with exacerbating features

Contacts

Primary Contactghada tony, doctora

ghadatony2003@gmail.com01117902713

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026