Aging, Alcohol Abstinence, Alcohol Drinking, Behavioral Problem, Binge Drinking, Blood Pressure, Lifestyle Factors, Vasodilation
Conditions
Keywords
Exercise training, High-intensity interval training, Midlife adults, Middle-aged, Microvascular function, Sympathetic nerve activity
Brief summary
This study has two phases: Phase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers/moderate drinkers. Phase 2 is to examine the effect of 8-week aerobic exercise training on blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers
Detailed description
During phase 1, we will measure blood pressure, microvascular function, and sympathetic nerve activity (baseline assessment) in mid-life adult binge drinkers, alcohol abstainers, and moderate drinkers. Only mid-life adult binge drinkers will enter Phase 2 and be randomized to the exercise training group and non-exercise control group. After 8 weeks of intervention, we will re-measure blood pressure, microvascular function, and sympathetic nerve activity (post-intervention assessment) in mid-life adult binge drinkers.
Interventions
BEHAVIORALExercise Training
Subjects will be asked to perform exercise training (high-intensity interval training) under supervision, 3 times per week for 8 weeks. Each training session will last 40 minutes and will consist of 10-minute warm up at 70% of maximal heart rate (HRmax), four 4-minute intervals at 90% of HRmax with 3-min active recovery at 70% of HRmax and 5-minute cool down at 70% of HRmax.
BEHAVIORALAlcohol Abstinence Intervention
Subjects will be asked to abstain from alcohol for 8 weeks. Education materials and bi-weekly consultations will be provided.
Sponsors
The University of Texas at Arlington
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 64 Years
Healthy volunteers
Yes
Inclusion criteria
* Men and women (50-64 years of age) who do not drink alcohol, who drink at moderate levels, or who binge drink * Female subjects will be postmenopausal (i.e., cessation of menses for ≥1 yr). * Subjects who can speak and understand English.
Exclusion criteria
* a history of diabetes, cardiovascular disease, liver, or renal disease * current or history of smoking and illicit drug use * blood pressure ≥160/100 mm Hg * other known traditional cardiovascular disease risks: obesity (BMI≥35 kg/m2), or hyperlipidemia (total cholesterol\>230 mg/dl and/or LDL cholesterol\>160 mg/dl) * active infection (in the past 2 months) * a history of seizures, cancer, or inflammatory disease (i.e., gout or rheumatoid) * unstable body weight (\>5% change during the past 6 months) * regular aerobic exercise training (i.e., they engage in 30 min of structured aerobic exercise at least 3 times per week) * current use of hormone replacement therapy (i.e., estrogen, progesterone, and testosterone)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Feasibility of high-intensity interval training | Through out the study participation (~3 months) | Recruitment capacity (e.g., how many subjects respond and enter to the study or reasons of refusal), resulting subject characteristics, the number of exercise session attended, and the number of dropouts |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in microvascular function | Baseline and after an 8-week intervention | A small amount of fat will be taken form the buttock. Small vessels will then be found in the fat and their sizes in response to various flows and chemical agents will be measured. |
| Changes in sympathetic activity | Baseline and after an 8-week intervention | A small electrode will be inserted into the back of the knee to record nerve activity (bursts/min). |
| Changes in urine catecholamine levels | Baseline and after an 8-week intervention | Urine samples will be collected for 24 hours to measure norepinephrine levels (ug/g) |
| Changes in blood pressure | Baseline and after an 8-week intervention | Systolic and Diastolic blood pressure will be measured at rest and for 24 hours. |
| Changes in alcohol intake | Baseline and after an 8-week intervention | Questionnaires will be used to determine alcohol intake. |
Countries
United States
Contacts
CONTACTChueh-Lung Hwang, PhD
PRINCIPAL_INVESTIGATORChueh-Lung Hwang, PhD
University of Texas at Arlington
Outcome results
None listed