Fine Needle Aspiration Cytology, Thyroid Diseases
Conditions
Keywords
FNAC, thyroid nodules, thyroidectomy
Brief summary
Thyroid gland diseases are the second most common endocrine disease following diabetes mellitus(1). Thyroid nodules are common disorders with a prevalence ranged from 4 to 7% in adult population, 5%-30% are malignant \[1\].Fine-needle aspiration cytology (FNAC) is an easy, cost-effective test for cancer diagnosis, and its use has markedly decreased the number of unnecessary thyroid surgeries(2).
Detailed description
it should be noted that FNAC cannot differentiate between benign and malignant follicular neoplasms.differentiation between follicular adenoma and follicular carcinoma is only possible after thyroid lobectomy.\[2,3\] In addition, a study of FNAC showed that 68% of the cases diagnosed by FNAC as follicular neoplasm turned out to be the follicular type of papillary carcinoma, indicting a considerable overlap between benign and malignant neoplasms.\[4\] Incidental findings of thyroid nodules have increased exponen¬tially in recent years, mostly due to the widespread application of high-resolution ultrasound (US) to the thyroid \[5\].Several in¬ternational scientific societies have established clinic-radiolog¬ical guidelines for the diagnosis and the management of thy¬roid nodules \[2,3\]. The American College of Radiology identifies 5 radiological risk levels and recommends US-guided fine-nee¬dle aspiration cytology (US-FNAC) of high-suspicion nodules if 10 mm or larger, and of nodules with a low risk for malignan¬cy only if larger than 25 mm \[2\]. According to the European Thyroid Association Guidelines (EU-TIRADS), nodules with no high-risk features (oval-shaped, isoechoic/hyperechoic with smooth margins) should be considered at low risk and FNA performed only if greater than 20 mm, while high-risk nodules greater than 10 mm should undergo FNAC, with possible FNAC also in 5-10 mm nodules if highly suspicious \[3\].
Interventions
PROCEDUREFine Needle Aspiration Cytology
Comparison between FNAC and post operative specimen after thyroid surgery
Sponsors
Qena Oncology Center
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
15 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Thyroid diseases * Multi nodullar * single nodules * diffuse goiter * Thyroid diseases underwent FNAC Then Thyroid surgery
Exclusion criteria
* Patients with no diagnostic FNAC
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of true positive results of FNAC after thyroidectomy | 10 days | Accuracy of FNAC in thyroid nodules compared to to surgical specimen : QOC experience |
| Percentage of malignant thyroid nodules not observed by FNAC | 10 days | type of thyroid malignancy not observed by FNAC |
| Incidence of false negative results by FNAC | 10 days | false negative that diagnosed by FNAC not malignant but proved malignancy after surgical excion |
| Percentage of Total number of true results of FNAC to the total number of cases | 10 days | accuracy of FNAC |
Countries
Egypt
Outcome results
None listed