Cardiovascular Diseases
Conditions
Brief summary
Use samples procured from patients to improve understanding of molecular, cellular, and tissue-level processes produced by a variety of cardiac diseases and therapeutic interventions.
Detailed description
This is a prospective study enrolling patients referred for or undergoing cardiovascular procedures or treatment at the University of Kentucky. The study aims to facilitate the discovery of novel diagnostic biomarkers and therapeutic targets and improve the pathophysiological understanding of cardiac conditions.
Interventions
None listed
Sponsors
Kenneth S. Campbell
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients undergoing evaluation of a cardiac condition or receiving a right heart catheterization with biopsy clinically indicated who are at least 18 years of age.
Exclusion criteria
* Patients without a cardiovascular or amyloidosis diagnosis, under 18 years of age.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Discover and quantify the concentration of novel diagnostic and prognostic biomarkers | 12/21/2021-12/31/2030 | Use biospecimens procured from patients with cardiac conditions to identify diagnostic surrogate biomarkers using discovery proteomics. In Cardiac Amyloidosis, the serum levels will be compared between confirmed ATTR and non-ATTR heart failure patients and a diagnostic threshold will be established. The research aims to advance understanding of cardiac diseases and to support the development of improved therapies. |
Countries
United States
Contacts
CONTACTKenneth S Campbell, PhD
CONTACTJennifer Isaacs, MS, MS
PRINCIPAL_INVESTIGATORKenneth S Campbell, PhD
University of Kentucky
Outcome results
None listed