Short-Term Anti-plaque Effect of Cymenol Mouthwash Analysed Using Dentius Deep Plaque Software

Randomised Clinical Trial on the Short-Term Anti-plaque Effect of Cymenol Mouthwash Analysed Using Dentius Deep Plaque Software

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05521230

Enrollment

Registered

2022-08-30

Start date

2021-09-01

Completion date

2022-04-30

Last updated

2022-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Plaque, Healthy

Brief summary

The objective of this project was to investigate the short-term in situ anti-plaque effect of cymenol, using the Dentius Deep Plaque software

Interventions

DRUGPlacebo Mouthwash

Application of mouthwashes

DRUGCymenol mouthwash

Application of mouthwashes

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

were as follows: * Systemically healthy volunteers * Age between 20-45 years * Presence of minimum of 24 permanent teeth * No evidence of gingivitis or periodontitis (CPITN= 0) * No presence of untreated caries at the start of the study.

Exclusion criteria

were as follows: * Smoker or ex-smoker * Presence of dentures or orthodontic appliances * Antibiotic treatment in the last 3 months or routine use of oral antiseptics

Design outcomes

Primary

Measure	Time frame	Description
Change in the plaque area: baseline vs 4 days	Baseline, 4 days	Change in the percentage of the tooth surface with dental plaque:baseline vs 4 days
Change in the plaque area: baseline vs 8 days	Baseline, 8 days	Change in the percentage of the tooth surface with dental plaque: baseline vs 8 days
Change in the plaque area: 4 days vs 8 days	4 days, 8 days	Change in the percentage of the tooth surface with dental plaque: 4 days vs 8 days
Change in the growth rate of dental plaque area: baseline vs 4 days	Baseline, 4 days	Change in the growth rate of dental plaque area (percentage area/hour): baseline vs 4 days
Change in the growth rate of dental plaque area: baseline vs 8 days	Baseline, 8 days	Change in the growth rate of dental plaque area (percentage area/hour): baseline vs 8 days
Change in the growth rate of dental plaque area: 4 days vs 8 days	4 days vs 8 days	Change in the growth rate of dental plaque area (percentage area/hour): 4 days vs 8 days

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 10, 2026