Colorectal Cancer
Conditions
Keywords
biomarkers
Brief summary
The aim of the study is to validate the value of value of peripheral blood protein biomarkers in colorectal cancer screening, and to identify new ones
Interventions
DIAGNOSTIC_TESTblood sampling for screening of biomarkers
Patient aged 50 years or older referred for screening colonoscopy after a positive fecal immunochemical test or for endoscopic resection of a previously identified suspicious colorectal lesion will have a blood sampling for biomarkers detection
Sponsors
University Hospital, Rouen
OncoDiag
University Hospital, Caen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient aged 50 years or older referred for screening colonoscopy after a positive FIT test or for endoscopic resection of a previously identified suspicious colorectal lesion
Exclusion criteria
* Very high risk of colorectal cancer: Lynch syndrome, Familial adenomatous polyposis, Peutz-Jeghers syndrome, Familial polyposis associated with a MutYH gene defect * Other solid cancers or haematological malignancies that are progressive and/or undergoing treatment (apart from basal cell skin carcinoma) * Contraindication to total colonoscopy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of patient with advanced neoplasia at colonoscopy | Day 1 |
| Number of patient with presence of best isolated serum biomarkers selected from different candidates | Day 1 |
Secondary
| Measure | Time frame |
|---|---|
| Number of patient with presence of other isolated serum biomarkers selected from different candidates | Day 1 |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORAdrien Grancher, MD
University Hospital, Rouen
Outcome results
None listed