Type2diabetes, SGLT2 Inhibitor, Urinary Tract Infection
Conditions
Brief summary
The SGLT2 inhibitors have changed the treatment of type 2 diabetes mellitus in recent years, especially in patients with cardiovascular or renal disease. However, the association between SGLT2 inhibitors and urinary tract infection (UTI) risk is controversial. Moreover, it is not known whether asymptomatic bacteriuria or urinalysis abnormality at the initiation of SGLT2 inhibitors are risk factors for UTI in women. There is not enough data to recommend or not to recommend for performing urinalysis or urine culture test before initiation of SGLT2 inhibitors. The aim of the study is to investigate the effect of asymptomatic bacteriuria or urinalysis abnormality at the initiation of SGLT2 inhibitors on UTI risk in a prospective cohort of women with type 2 diabetes mellitus.
Interventions
DIAGNOSTIC_TESTurine culture and urinalysis
urine culture and urinalysis
Sponsors
Trabzon Arakli Bayram Halil Public Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Female * \>18 years old * Type 2 Diabetes Mellitus * Initiated SGLT2 inhibitors * Available informed consent
Exclusion criteria
* Having urinary tract or genital tract symptoms at the enrollment * Treated for urinary tract or genital tract infection in the last 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urinary tract infection | 3 months | Number of participants with urinary tract infection - Any urinary tract infection treated or diagnosed by the physician clinically or by testing |
Countries
Turkey (Türkiye)
Contacts
Primary ContactErman Akkus, MD
Outcome results
None listed