Pregnancy Preterm, Preterm Labor Without Delivery
Conditions
Keywords
Nifedipine, Magnesium sulfate, pregnancy, preterm labor threat
Brief summary
Comparison of the effects of Nifedipine and MgSO4 therapies on maternal and fetal blood flow.
Detailed description
In this study, the investigators aim to compare the effect of Nifedipine and MgSO4 therapies on Doppler parameters of the uterine, umbilical, middle cerebral arteries, and ductus venous in the first 48 hours of therapy in pregnancies with preterm labor threat and also compare perinatal outcomes after delivery between the groups.
Interventions
DRUGNifedipine
A total of 30 pregnancies with preterm labor threats will be treated with Nifedipine.
DRUGMagnesium sulfate
A total of 30 pregnancies with preterm labor threats will be treated with Magnesium sulfate.
Sponsors
Konya Meram State Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 38 Years
Healthy volunteers
Yes
Inclusion criteria
* pregnancies with preterm labor threat between 28-34 weeks gestational ages
Exclusion criteria
* Cervical dilatation at \> 4 cm and/or cervical effacement \>80%, * Multiple pregnancies, * Pregnancy complications including preeclampsia, ablatio placenta, intrauterine growth restriction, placenta previa, gestational diabetes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Doppler parameters | Gestational age at delivery (weeks) | Pulsality index of middle cerebral artery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Perinatal outcomes | Gestational age at delivery (weeks) | NICU admission |
Countries
Turkey (Türkiye)
Contacts
Primary ContactMerve Turk
Outcome results
None listed