Autonomic Dysfunction, Insulin Resistance, Obesity
Conditions
Brief summary
The aim of this project is to determine role for ET-1 in individuals with obesity.
Interventions
DRUGHyperinsulinemic, euglycemic infusion
60 minute infusion
Sponsors
University of Missouri-Columbia
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-55 years of age * Male sex * Obese (BMI ≥30 kg/m2)
Exclusion criteria
* Female sex * Current smoking/Nicotine use * Nerve/neurologic disease * Cardiovascular, hepatic, renal, respiratory disease * Blood pressure ≥140/90 mmHg * Diabetes * Vigorous exercise \>3 times/week * Communication barriers * taking any medications known to affect metabolic, respiratory, cardiovascular, and/or autonomic
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Amount of muscle sympathetic nerve activity (MSNA) | Change from baseline at minute 60 | MSNA burst incidence (bursts/100 heart beats) |
| Amount of leg blood flow | Change from baseline at minute 60 | Measured with Doppler ultrasound (mL/min) |
Outcome results
None listed