Low Flow Anesthesia, Normal Flow Anesthesia, Robotic Surgery
Conditions
Brief summary
Robot-assisted laparoscopic radical prostatectomy has gained increasing popularity compared to open radical prostatectomy with its advantages such as low blood loss, reduced blood transfusion rate, low complication rate, and shortened hospital stay. Since robot-assisted laparoscopic radical prostatectomy should be performed in the limited retroperitoneal area, insufflation of the abdomen with carbon dioxide (CO2) (pneumoperitoneum) and steep Trendelenburg position are required to provide better surgical vision. Low-flow anesthesia warms and moistens the inhaled gases, creating a more physiological breathing atmosphere during anesthesia. In addition, it provides cost advantage by reducing inhalation agent consumption and reduces atmospheric pollution. Studies show that long-term minimal flow anesthesia is safe and advantageous for non-laparoscopic surgery. The aim of this study is to compare low-flow (1L/min) with normal flow (3lt/min) desflurane anesthesia in terms of hemodynamic and respiratory parameters, inhalation agent consumption and soda lime consumption for robotic assisted laparoscopic radical prostatectomy surgery. The secondary aim of the study is to compare the effects of low-flow and normal-flow anesthesia in the steep trendelenburg position (45°) used for robotically assisted laparoscopic radical prostatectomy.
Interventions
Patients who will undergo robotic-assisted laparoscopic prostatectomy surgery
Sponsors
Ankara City Hospital Bilkent
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
\- ASA I-II-III risk group
Exclusion criteria
* ASA IV, V, * concomitant serious cardiac, respiratory, hepatic, renal disturbance, * mental status disorder and hearing problem, * anxiety and depression and/or other psychiatric disorders, * patient's refusal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| inspiratory O₂ concentration | from beginning of anesthesia induction to the end of anesthesia (during periopertaive period) | inspiratory O₂ concentration is measured from anesthesia machine monitor |
| partial oxygen pressure | from beginning of anesthesia induction to the end of anesthesia (during periopertaive period) | PO2 from blood gas analysis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| desflurane consumption | perioperative | desflurane consumption at the end of anesthesia is measured from anesthesia machine monitor |
| changes in liver and kidney function tests from the preoperative values to 48 hours postoperative | during operation and 48 hours postoperative | to determine the changes in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine from the preoperative values to 48 hours postoperative |
Countries
Turkey (Türkiye)
Outcome results
None listed