Facial Expression, Glabellar Frown Lines, Rhytides, Wrinkle
Conditions
Keywords
Botulinum Toxin, EMG-Guided Botulimun toxin injection, Cosmetic Botulinum toxin, Glabellar Merz Scale
Brief summary
The aim of this study was to compare between the conventional palpation method of botulinum toxin type A injection and the electromyography-guided method using clinical parameters and electromyography analysis.
Detailed description
The study was conducted on 15 healthy-looking female subjects with visible glabellar rhytids when frowning. All participants were recruited from the outpatient clinic of Dermatology Department, Main University Hospital, Faculty of Medicine, Alexandria University. The mean age was 46.27 ± 6.31 with a range from 33 to 59 years. All 15 subjects completed the study. Each subject provided a right and left corrugator supercilii muscles to the study. Each muscle was divided into a body and a tail, each part injected separately (n=60). Neurotoxin injection into the corrugator body and tail by palpation method on one side and under EMG-guidance on the other. Photographs were taken both at rest, and while frowning at each visit: pre-operatively, after 2 weeks and after 3 months. Clinical grading according to static and dynamic Merz glabellar frown line scales and EMG analysis was done at each visit: pre-operatively, after 2 weeks and after 3 months.
Interventions
DEVICEElectromyography-Needle Intramuscular Drug guidance
EMG-guided needle neurotoxin injection
DRUGBotulinum toxin type A
Botulinum toxin type A injection into the Corrugator Supercilii muscle
Sponsors
Mohamed Hayder Oleish Salih
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Split-Face: comparing two neurotoxin injection techniques, conventional palpation vs. EMG-guided injection. Follow up using EMG analysis and Glabellar Merz Scales
Eligibility
Sex/Gender
ALL
Age
25 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Consent. * Patients within age range of 25 - 60 years. * Visible corrugator muscle rhytids when frowning by examination.
Exclusion criteria
* Patients with no, or minimal wrinkles on the studied area. * Previous use of botulinum toxin in the previous 6 months. * Patients on regular or very occasional antispasmodics. * Patients with any neuromuscular disorders, infections or skin problems at the injection site. * Patients with any known neurological disease. * Patients who undergone surgery involving the glabellar area.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Interferance pattern Envelop amplitude (IPEA) | 3 months | difference between + and - spikes in the EMG waveform \[microvolt\] |
| Muscle activity percentage (MAp) | 3 months | percentage difference between the IPEA at follow up and base line \[%\] |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Glabellar Merz scales | 3 months | Glabellar Merz scales : Dunamic and static \[0-4\] |
Countries
Egypt
Outcome results
None listed