Efficacy, Self
Conditions
Brief summary
Objective: To determine efficacy of dexamethasone in treatment of meconium aspiration syndrome. Study design: Randomized control trial. Place and duration: Services hospital, Neonatal unit, Lahore. During time span of 1st January to 30th June 2021. Material and methods Total 100 neonates were randomly divided in two groups. Group A (n=50) was treated with dexamethasone (Cases) and Group B (n=50) served as control. Dexamethasone was given in dose of 0.2mg/kg, 12 hourly for 7 days after confirmation of diagnosis. Infants present in clinical trial were evaluated by ventilation duration (invasive and non-invasive), oxygen therapy and hospital stay.
Detailed description
Data was analyzed in statistical analysis SPSS version 23. Means and Standard deviation were calculated for duration of non-invasive and invasive ventilation, hospital stay and oxygen therapy. Independent sample T test was applied and value \< 0.05 was taken as significant. Whereas frequency and percentages were taken for gender, gestation, mode of delivery and outcome of MAS and Chi-square test was applied, and p value \< 0.05 was taken as significant.
Interventions
DRUGDexamethasone
Randomized clinical trial
Sponsors
Services Institute of Medical Sciences, Pakistan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 24 Hours
Healthy volunteers
No
Inclusion criteria
1. Term and Post-Term babies who met the operational definition of MAS (inborn) 2. Presenting within 24 hours of life
Exclusion criteria
1. Preterm babies or babies with congenital malformations 2. Preterm babies or babies with dysmorphism 3. Preterm babies or babies with hypoxic-ischemic encephalopathy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The number of days required for ventilation in participants | 7 days | The purpose of study was to measure number of days required for ventilation in participants |
| The number of days required for oxygen therapy in participants | 7 days | The purpose of study was to measure number of days required for oxygen therapy in participants |
| The number of days required for hospitalization in participants | 7 days | The purpose of study was to measure number of days required for hospitalization in participants |
Countries
Pakistan
Outcome results
None listed