Rocuronium, Body Composition
Conditions
Brief summary
The induction dose of rocuronium is typically decided based on the patient's body weight, but the effect duration of rocuronium is variable. Some studies suggest that body composition analysis data, such as skeletal muscle mass or total body water, may correlate better with the duration time of rocuronium. Therefore, we plan to analyse body composition in patients undergoing total intravenous general anesthesia, give the patients a fixed dose (50mg) of rocuronium, and check the correlation between duration time of rocuronium and body composition analysis data.
Interventions
Patients will undergo body composition analysis using bioelectical impedance method before anesthesia.
Sponsors
Samsung Medical Center
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients with ASA class I-II undergoing total intravenous general anesthesia
Exclusion criteria
* too overweight (over 111.11kg, which corresponds to less than 0.45mg/kg of induction dose of rocuronium) * too underweight (under 41.67kg, which corresponds to more than 1.2mg/kg of induction dose of rocuronium) * pregnancy * prediagnosed muscle or nerve related disease * unsuitable for body composition analysis using bioelectrical impedance method * unsuitable for neuromuscular block monitoring
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| time to TOF1 | up to 1 hour after rocuronium administration during induction of anesthesia | correlation between the time from induction to recovery of 1st TOF twitch and age, sex, ASA class, body weight, and body composition analysis data |
| time to TOF4 | up to 1.5 hour after rocuronium administration during induction of anesthesia | correlation between the time from induction to recovery of 4th TOF twitch and age, sex, ASA class, body weight, and body composition analysis data |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| time to loss of TOF | up to 5 minutes after rocuronium administration during induction of anesthesia | correlation between the time from injection of rocuronium to complete loss of TOF twitch and age, sex, ASA class, body weight, and body composition analysis data |
Countries
South Korea
Outcome results
None listed