Microbial Colonization
Conditions
Keywords
Gut Microbiome, Clostridioides difficile
Brief summary
Given the clinical need to improve upon current antibiotic regimens for the treatment of C. difficile infection with a particular focus on the impact of therapies on gut microbiome, this study proposes to characterize the impact of Intravenous (IV) omadacycline on gut microbiome of healthy volunteers.
Detailed description
The plan to enroll eight healthy volunteers between the ages of 18 and 40 years and without history of cardiovascular, gastrointestinal, hepatic, or renal disease to receive 5 days of intravenous omadacycline followed by 5 days of oral omadacycline. Stool and saliva samples will be collected at pre-specified times and analyzed to characterize the impact of IV omadacycline on gut microbiome.
Interventions
DRUGOmadacycline Injection
All participants will receive Intravenous (IV) omadacycline
Sponsors
University of Houston
High Point University
Paratek Pharmaceuticals Inc
Wake Forest University Health Sciences
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-40 years of age * Willing and able to comply with all study procedures * Considered healthy without history of cardiovascular, gastrointestinal, hepatic, or renal disease * males or females - females of child bearing potential must agree to use a highly effective contraception during the study and for at least 7 days after the last dose of omadacycline
Exclusion criteria
* Consumed probiotics within 30 days before enrollment * Consumed antibiotics within 90 days prior to enrollment * Known hypersensitivity to omadacycline or tetracycline-class antibiotics * pregnant or breastfeeding * in the opinion of the investigator is experiencing signs or symptoms of acute illness that increase the risk of adverse effects from participating in the study * previously participated in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Phylum Level Mean Proportional Relative Abundance | Day 30 | In general, the healthy volunteer analyses will assess changes in total and species-specific microbiota over time as well as changes in microbial diversity. |
| Bacterial DNA Per Gram of Stool | Baseline | nanograms (ng) per gram of stool for bacterial DNA |
| Order Level Mean Proportional Relative Abundance | Baseline | Order Level Mean Proportional Relative Abundance - Relative abundance % for order |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Intravenous (IV) Omadacycline All participants will receive 5 days of IV omadacycline followed by 5 days of oral omadacycline
Omadacycline Injection: All participants will receive Intravenous (IV) omadacycline | 8 |
| Total | 8 |
Baseline characteristics
| Characteristic | Intravenous (IV) Omadacycline |
|---|---|
| Age, Continuous | 29.875 years STANDARD_DEVIATION 4.2 |
| Ethnicity (NIH/OMB) Hispanic or Latino | 2 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 6 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants |
| Race (NIH/OMB) Asian | 0 Participants |
| Race (NIH/OMB) Black or African American | 0 Participants |
| Race (NIH/OMB) More than one race | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) White | 8 Participants |
| Sex: Female, Male Female | 4 Participants |
| Sex: Female, Male Male | 4 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 0 / 8 |
| other Total, other adverse events | 7 / 8 |
| serious Total, serious adverse events | 0 / 8 |
Outcome results
Primary
Bacterial DNA Per Gram of Stool
nanograms (ng) per gram of stool for bacterial DNA
Time frame: Baseline
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Bacteroides thetaiotaomicron | 2.74 10^7 ng/g | Standard Deviation 6.11 |
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Blautia coccoides | 608 10^7 ng/g | Standard Deviation 2.39 |
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Clostridium leptum | 3.84 10^7 ng/g | Standard Deviation 1.73 |
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Prevotella | 14.9 10^7 ng/g | Standard Deviation 46.6 |
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Eubacteria | 2220 10^7 ng/g | Standard Deviation 953 |
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Enterobacteriaceae | 1.42 10^7 ng/g | Standard Deviation 5.57 |
Primary
Bacterial DNA Per Gram of Stool
nanograms (ng) per gram of stool for bacterial DNA
Time frame: End of Therapy up to Day 10
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Bacteroides thetaiotaomicron | 0.849 10^7 ng/g | Standard Deviation 1.43 |
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Blautia coccoides | 9.97 10^7 ng/g | Standard Deviation 14.7 |
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Clostridium leptum | .0148 10^7 ng/g | Standard Deviation 0.013 |
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Prevotella | 4.25 10^7 ng/g | Standard Deviation 7.3 |
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Eubacteria | 103 10^7 ng/g | Standard Deviation 113 |
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Enterobacteriaceae | 21.9 10^7 ng/g | Standard Deviation 37.4 |
Primary
Bacterial DNA Per Gram of Stool
nanograms (ng) per gram of stool for bacterial DNA
Time frame: During Therapy up to Day 6
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Eubacteria | 197 10^7 ng/g | Standard Deviation 157 |
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Enterobacteriaceae | 9.77 10^7 ng/g | Standard Deviation 31.5 |
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Bacteroides thetaiotaomicron | .954 10^7 ng/g | Standard Deviation 3.05 |
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Blautia coccoides | 30.0 10^7 ng/g | Standard Deviation 22.9 |
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Clostridium leptum | .0488 10^7 ng/g | Standard Deviation 0.0553 |
| Intravenous (IV) Omadacycline | Bacterial DNA Per Gram of Stool | Prevotella | 2.41 10^7 ng/g | Standard Deviation 22.8 |
Primary
Order Level Mean Proportional Relative Abundance
Order Level Mean Proportional Relative Abundance - Relative abundance % for order
Time frame: Day 10
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Actinobacteriota o_Bifidobacteriales | 0.164 Relative abundance % for order | Standard Deviation 0.0979 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Actinobacteriota o_Coriobacteriales | 0.0324 Relative abundance % for order | Standard Deviation 0.0368 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacteroidota o_Bacteroidales | 0.0459 Relative abundance % for order | Standard Deviation 0.0848 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Euryarchaeota o_Methanobacteriales | 0.152 Relative abundance % for order | Standard Deviation 0.262 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Erysipelotrichales | 0.229 Relative abundance % for order | Standard Deviation 0.0546 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Lachnospirales | 0.0616 Relative abundance % for order | Standard Deviation 0.0473 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Lactobacillales | 0.0128 Relative abundance % for order | Standard Deviation 0.0104 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Oscillospirales | 0.0363 Relative abundance % for order | Standard Deviation 0.0725 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Peptostreptococcales- Tissierellales | 0.0156 Relative abundance % for order | Standard Deviation 0.0238 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Veillonellales- Selenomonadales | 0.0915 Relative abundance % for order | Standard Deviation 0.142 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Verrucomicrobiota o_Verrucomicrobiales | 0.210 Relative abundance % for order | Standard Deviation 0.203 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Proteobacteria o_Enterobacterales | 0.147 Relative abundance % for order | Standard Deviation 0.112 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | Other Orders <2% | 0.00783 Relative abundance % for order | Standard Deviation 0.00772 |
Primary
Order Level Mean Proportional Relative Abundance
Order Level Mean Proportional Relative Abundance - Relative abundance % for order
Time frame: Baseline
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Actinobacteriota o_Bifidobacteriales | 0.0349 Relative abundance % for order | Standard Deviation 0.0265 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Actinobacteriota o_Coriobacteriales | 0.0925 Relative abundance % for order | Standard Deviation 0.0389 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacteroidota o_Bacteroidales | 0.0135 Relative abundance % for order | Standard Deviation 0.0152 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Euryarchaeota o_Methanobacteriales | 0.0388 Relative abundance % for order | Standard Deviation 0.0933 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Erysipelotrichales | 0.0693 Relative abundance % for order | Standard Deviation 622 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Lachnospirales | 0.417 Relative abundance % for order | Standard Deviation 0.157 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Lactobacillales | 0.0429 Relative abundance % for order | Standard Deviation 0.0273 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Oscillospirales | 0.188 Relative abundance % for order | Standard Deviation 0.0883 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Peptostreptococcales- Tissierellales | 0.0213 Relative abundance % for order | Standard Deviation 0.0109 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Veillonellales- Selenomonadales | 0.0107 Relative abundance % for order | Standard Deviation 0.00754 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Verrucomicrobiota o_Verrucomicrobiales | 0.0173 Relative abundance % for order | Standard Deviation 0.0227 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Proteobacteria o_Enterobacterales | 0.0204 Relative abundance % for order | Standard Deviation 0.0342 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | Other Orders <2% | 0.0336 Relative abundance % for order | Standard Deviation 0.032 |
Primary
Order Level Mean Proportional Relative Abundance
Order Level Mean Proportional Relative Abundance - Relative abundance % for order
Time frame: Day 5
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Actinobacteriota o_Bifidobacteriales | 0.105 Relative abundance % for order | Standard Deviation 0.0358 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Actinobacteriota o_Coriobacteriales | 0.120 Relative abundance % for order | Standard Deviation 0.0314 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacteroidota o_Bacteroidales | 0.0507 Relative abundance % for order | Standard Deviation 0.0812 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Euryarchaeota o_Methanobacteriales | 0.000447 Relative abundance % for order | Standard Deviation 0.0001 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Erysipelotrichales | 0.0148 Relative abundance % for order | Standard Deviation 0.0143 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Lachnospirales | 0.204 Relative abundance % for order | Standard Deviation 0.0845 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Lactobacillales | 0.0505 Relative abundance % for order | Standard Deviation 0.0632 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Oscillospirales | 0.0653 Relative abundance % for order | Standard Deviation 0.0507 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Peptostreptococcales- Tissierellales | 0.0163 Relative abundance % for order | Standard Deviation 0.0161 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Veillonellales- Selenomonadales | 0.0685 Relative abundance % for order | Standard Deviation 0.0881 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Verrucomicrobiota o_Verrucomicrobiales | 0.131 Relative abundance % for order | Standard Deviation 0.106 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Proteobacteria o_Enterobacterales | 0.158 Relative abundance % for order | Standard Deviation 0.141 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | Other Orders <2% | 0.0175 Relative abundance % for order | Standard Deviation 0.0168 |
Primary
Order Level Mean Proportional Relative Abundance
Order Level Mean Proportional Relative Abundance - Relative abundance % for order
Time frame: Day 30
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Actinobacteriota o_Bifidobacteriales | 0.0880 Relative abundance % for order | Standard Deviation 0.0515 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Actinobacteriota o_Coriobacteriales | 0.0779 Relative abundance % for order | Standard Deviation 0.053 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacteroidota o_Bacteroidales | 0.0270 Relative abundance % for order | Standard Deviation 0.0313 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Euryarchaeota o_Methanobacteriales | 0.0391 Relative abundance % for order | Standard Deviation 0.103 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Erysipelotrichales | 0.0356 Relative abundance % for order | Standard Deviation 0.0365 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Lachnospirales | 0.416 Relative abundance % for order | Standard Deviation 0.169 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Lactobacillales | 0.0306 Relative abundance % for order | Standard Deviation 0.0265 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Oscillospirales | 0.0971 Relative abundance % for order | Standard Deviation 0.0941 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Peptostreptococcales- Tissierellales | 0.0271 Relative abundance % for order | Standard Deviation 0.0197 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Bacillota o_Veillonellales- Selenomonadales | 0.0657 Relative abundance % for order | Standard Deviation 0.119 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Verrucomicrobiota o_Verrucomicrobiales | 0.0371 Relative abundance % for order | Standard Deviation 0.075 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | p_Proteobacteria o_Enterobacterales | 0.0400 Relative abundance % for order | Standard Deviation 0.0611 |
| Intravenous (IV) Omadacycline | Order Level Mean Proportional Relative Abundance | Other Orders <2% | 0.0186 Relative abundance % for order | Standard Deviation 0.0198 |
Primary
Phylum Level Mean Proportional Relative Abundance
In general, the healthy volunteer analyses will assess changes in total and species-specific microbiota over time as well as changes in microbial diversity.
Time frame: Day 30
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Actinobacteriota | 0.167 % gram positive (+) for phylum | Standard Deviation 0.0622 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Bacteroidota | 0.0271 % gram positive (+) for phylum | Standard Deviation 0.0314 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Bacillota | 0.686 % gram positive (+) for phylum | Standard Deviation 0.114 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Euryarchaeota | 0.0391 % gram positive (+) for phylum | Standard Deviation 0.103 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Verrucomicrobiota | 0.0371 % gram positive (+) for phylum | Standard Deviation 0.075 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Proteobacteria | 0.0399 % gram positive (+) for phylum | Standard Deviation 0.061 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Other Phyla <2% | 0.00324 % gram positive (+) for phylum | Standard Deviation 0.00809 |
Primary
Phylum Level Mean Proportional Relative Abundance
In general, the healthy volunteer analyses will assess changes in total and species-specific microbiota over time as well as changes in microbial diversity.
Time frame: Day 10
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Actinobacteriota | 0.198 % gram positive (+) for phylum | Standard Deviation 0.101 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Bacteroidota | 0.0459 % gram positive (+) for phylum | Standard Deviation 0.0848 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Bacillota | 0.246 % gram positive (+) for phylum | Standard Deviation 0.191 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Euryarchaeota | 0.152 % gram positive (+) for phylum | Standard Deviation 0.262 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Verrucomicrobiota | 0.210 % gram positive (+) for phylum | Standard Deviation 0.203 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Proteobacteria | 0.147 % gram positive (+) for phylum | Standard Deviation 0.112 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Other Phyla <2% | 0.00105 % gram positive (+) for phylum | Standard Deviation 0.00144 |
Primary
Phylum Level Mean Proportional Relative Abundance
In general, the healthy volunteer analyses will assess changes in total and species-specific microbiota over time as well as changes in microbial diversity.
Time frame: Day 5
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Actinobacteriota | 0.225 % gram positive (+) for phylum | Standard Deviation 0.0469 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Bacteroidota | 0.0507 % gram positive (+) for phylum | Standard Deviation 0.0812 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Bacillota | 0.432 % gram positive (+) for phylum | Standard Deviation 0.0814 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Euryarchaeota | 0 % gram positive (+) for phylum | Standard Deviation 0.0001 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Verrucomicrobiota | 0.131 % gram positive (+) for phylum | Standard Deviation 0.106 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Proteobacteria | 0.158 % gram positive (+) for phylum | Standard Deviation 0.141 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Other Phyla <2% | 0.00310 % gram positive (+) for phylum | Standard Deviation 0.00407 |
Primary
Phylum Level Mean Proportional Relative Abundance
In general, the healthy volunteer analyses will assess changes in total and species-specific microbiota over time as well as changes in microbial diversity.
Time frame: Baseline
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Actinobacteriota | 0.130 % gram positive (+) for phylum | Standard Deviation 0.039 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Bacteroidota | 0.0135 % gram positive (+) for phylum | Standard Deviation 0.0152 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Bacillota | 0.779 % gram positive (+) for phylum | Standard Deviation 0.0879 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Euryarchaeota | 0.0388 % gram positive (+) for phylum | Standard Deviation 0.0933 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Verrucomicrobiota | 0.0173 % gram positive (+) for phylum | Standard Deviation 0.0227 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Proteobacteria | 0.0205 % gram positive (+) for phylum | Standard Deviation 0.0342 |
| Intravenous (IV) Omadacycline | Phylum Level Mean Proportional Relative Abundance | Other Phyla <2% | 0.00110 % gram positive (+) for phylum | Standard Deviation 0.0019 |