Gastric Cancer, Gastroesophageal Reflux Disease, Proximal Gastric Adenocarcinoma
Conditions
Brief summary
This research is designed to compare proximal gastrectomy anterior anastomosis with pyloroplasty with esophagogastric anastomosis for gastric cancer. Gastroesophageal reflux disease, postoperative quality of life, short term outcomes, and long term outcomes will be compared.
Interventions
PROCEDUREProximal Gastrectomy Anterior Anastomosis With Pyloroplasty
The location of the anastomosis in the anterior of the gastric stump. Pyloroplasty is added in the procedure
Sponsors
Nanchong Central Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
1. Histologically confirmed adenocarcinoma of the stomach, T1-T4 stages. 2. Eastern Cooperative Oncology Group performance status of 0 or 1. 3. Adequate organ function.
Exclusion criteria
1. Patients had distant metastasis. 2. oesophageal invasion of more than 3 cm. 3. Borrmann type 4 or large (more than 8 cm) type 3 carcinoma. 4. Previous chemotherapy or radiation therapy for any other malignancies.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gastroesophagus reflux disease apprised by ph monitoring | 6 months | Ph monitoring by wireless or wire device |
| Gastroesophagus reflux disease apprised by questionnaire | 6 months | PGSAS-45 questionnaire is adopted. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Surgical complications of proximal gastrectomy for gastric cancer | 1 year | Surgical complications include anastomotic leakage, anastomotic stricture, postoperative bleeding, pleural effusion, et al. |
| Long-term outcome | 5 years | Total survival time after proximal gastrectomy for gastric cancer |
Countries
China
Outcome results
None listed