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Conversion of Labor Analgesia for Intrapartum Cesarean Delivery: DPE v CSE v Epidural

Conversion of Labor Analgesia for Intrapartum Cesarean Delivery: Dural Puncture Epidural vs Combined Spinal Epidural vs Epidural

Status
Enrolling by invitation
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05514431
Enrollment
1500
Registered
2022-08-24
Start date
2017-02-01
Completion date
2027-07-01
Last updated
2026-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgesia, Anesthesia

Keywords

epidural, cesarean, parturient

Brief summary

As the dural puncture epidural (DPE) is increasing in popularity for labor analgesia, it is important to understand how it impacts outcomes in parturients. Prior studies have found epidural catheters placed via the combined-spinal epidural technique have greater success at surgical conversion for cesarean delivery than catheters placed via traditional techniques. The investigators aim to determine if epidural catheters placed by a DPE technique will also have an increased successful conversion for surgical anesthesia by conducting a retrospective review of all CD during the study period. If an association is found, this could be another benefit of DPE for labor analgesia.

Detailed description

Electronic medical records will be searched for all intrapartum cesarean deliveries performed from February 1, 2017 through May 30, 2021 (Mayo Clinic) and from January 1, 2022 to December 31, 2022 (BC Women's Hospital). From this list, patients that had cesarean delivery with an epidural catheter will be identified and split into three groups based on the type of neuraxial block listed in the block document of the patient's medical record: Group 1 - Dural puncture epidural Group 2 - Epidural Group 3 - Combined spinal-epidural Failure of epidural catheter conversion to surgical anesthesia at cesarean delivery will be defined by requirement of a second anesthetic at the time of surgery, including spinal or repeat epidural techniques or general anesthesia at the time of cesarean delivery Data Collection: All data will be collected retrospectively from the electronic medical record. 1. Type of neuraxial block 2. Size of needle used for DPE or CSE: 25 g or 27 g 3. Duration of time from epidural placement until CD (Time of epidural placement; time of delivery) 4. Number of epidural top-ups 5. Type and amount of medication used for conversion to surgical anesthesia 6. Urgency of cesarean delivery 7. Airway documentation indicative of general anesthesia (if applicable) 8. Length (time) of surgical procedure Other data collected from patient electronic records will include: 1. Maternal demographics: Parity, number of prior cesarean deliveries, weight, height, BMI 2. Fetal characteristics (birthweight, Apgar scores) 3. Indication for cesarean delivery 1. Fetal distress (NRFHT, fetal intolerance of labor) 2. Failure of labor (Failure to dilate, failure to descend) 3. Failed operative vaginal delivery 4. Maternal comorbidity 5. Emergency (cord prolapse, abruption, uterine rupture) 4. Anesthesiologist (Fellowship trained: Y/N) at time of cesarean delivery

Interventions

PROCEDUREEpidural

Traditional epidural catheter placement

Epidural catheters placed via DPE technique

PROCEDURECombined Spinal-Epidural (CSE) technique

Epidural catheters placed via CSE technique

Sponsors

Mayo Clinic
Lead SponsorOTHER
University of British Columbia
CollaboratorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Healthy volunteers
Yes

Inclusion criteria

1. Women with neuraxial labor analgesia (CSE, DPE, or Epidural) who have an intrapartum cesarean delivery 2. Singleton gestation

Exclusion criteria

1. No local anesthetic given in epidural for cesarean delivery (in emergency situation) 2. Inadvertent dural puncture

Design outcomes

Primary

MeasureTime frameDescription
Conversion to surgical anesthesiaBaselineNumber of subject to have success of conversion to surgical anesthesia for intrapartum cesarean delivery

Countries

Canada, United States

Contacts

PRINCIPAL_INVESTIGATOREmily Sharpe, MD

Mayo Clinic

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 3, 2026