The Impact of Intravenous Vitamin C Combined With Nerve Blocks on Postoperative Pain and Recovery After Total Knee Arthroplasty

The Impact of Intravenous Vitamin C Combined With Nerve Blocks on Postoperative Pain and Recovery After Total Knee Arthroplasty.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05514197

Enrollment

Registered

2022-08-24

Start date

2022-11-02

Completion date

2024-01-11

Last updated

2025-11-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ascorbic Acid, Postoperative Pain

Keywords

Ascorbic Acid, Total knee arthroplasty, Regional analgesia

Brief summary

The aim of this prospective randomized-control study was to evaluate the impact of a single high-dose intravenous vitamin C added to ultrasound-guided blocks at induction on postoperative pain, sngception and early functional rehabilitation of the knee joint in patients under-going total knee arthroplasty.

Interventions

DRUGAscorbic acid 100mg/kg, Maximus 10g

Intravenous loading of 100mg/kg ascorbic acid with normal saline, totally 100ml Completed before induction

DRUGControl Rx

Intravenous loading 100ml normal saline

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

50 Years to 80 Years

Healthy volunteers

Inclusion criteria

1. Physical status according to American Society of Anesthesiologists (ASA) I-III 2. Patients scheduled for total knee arthroplasty 3. Patients aged ranging from 50 to 80 years old

Exclusion criteria

1. Previous operation on the same knee 2. Allergy or intolerance to one of the study medications 3. Coagulopathy 4. Having lower limbs neuropathy 5. End-organ failure (CKD stage IV or V, NYHA III or IV) 6. BMI \> 35 7. Chronic opioid use (\>3 months) or drug abuser 8. Difficulty in communication (Impaired mental status) 9. Hyperuricemia or Glucose-6-phosphate dehydrogenase deficiency patient

Design outcomes

Primary

Measure	Time frame	Description
Numeric rating scale for pain	15 minutes postoperatively	11-point numeric scale ranges from '0' representing no pain to '10' representing the extreme pain
Numeric rating scale for soreness (Sngception)	15 minutes after surgery	11-point numeric scale ranges from '0' representing no soreness to '10' representing the extreme soreness

Secondary

Measure	Time frame	Description
Severity of postoperative nausea/ vomiting and dizziness	48 hours postoperatively	From 0 to 5, 0: non, 1: mild, 2: moderate, 3: severe, 4: unbearable
Time to first rescue morphine requirement at post-anesthetic care unit	up to 2 hours	Duration from arriving post-anesthetic care unit to requiring first morphine injection
Morphine consumption	48 hours postoperatively	Amount of IV morphine consumption postoperatively

Other

Measure	Time frame	Description
Blood ascorbic acid concentration	Preoperative baseline and postoperative day1	Blood ascorbic acid analysis
PostOP Knee joint range of motion	72 hours postoperatively	In degree from zero to 170

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026