Parkinson Disease
Conditions
Brief summary
In order to develop an image analysis system that automatically detects and quantifies neuromelanin, this study aims to construct a database of a wide sample by collecting brain MRI neuromelanin images prospectively.
Interventions
DEVICEMRI Imaging
Neuromelanin sequence imaging
Sponsors
Heuron Inc.
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Parkinsin group Inclusion Criteria: * Adults over 19 years old * Those who have clinically shown Parkinson's symptoms such as tremor, Rigidity, Bradykinesa and gait disturbance and are scheduled to take MRI scans * Dopamine transporter imaging shows a significant decrease in visual dopamine intake * A person who can read and understand the description and informed consent form * Upon hearing and fully understanding the detailed explanation of this clinical trial, a person who has voluntarily decided to participate and agreed in writing to comply with the precautions
Exclusion criteria
* Patient with a history of claustrophobia and mental illness; * Patient with metallic substances in the body * Any female subject who is likely to be pregnant who does not agree to contraception in a medically permitted manner during this clinical trial period * Pregnant or lactating women * Other cases where the investigator judged that it is difficult to participate in the study; Healthy volunteer group Inclusion Criteria: * Adults over 19 years old * A person who has no family history or diagnostic history of movement disorders; * A person with a score of 8 or higher on the CCSIT(cross cultural smell identification test) * A person with a score of 27 or higher on the MMSE Test * No Parkinson's symptoms on a neurological examination * Upon hearing and fully understanding the detailed explanation of this clinical trial, a person who has voluntarily decided to participate and agreed in writing to comply with the precautions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences in Neuromelanin Volume by Age | Within 1 weeks after enrollment | Descriptive Statistics for Neuromelanin Volume Measured by MRI Image by Age |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Differences in Neuromelanin Volume by group | Within 1 weeks after enrollment | Descriptive Statistics for Neuromelanin Volume Measured by MRI Image by group |
Countries
South Korea
Outcome results
None listed