Opioid Free Pterygopalatine Ganglion Block Based Multimodal Anesthesia for Tonsillectomy Operations

Comparative Study Between Opioid Free Pterygopalatine Ganglion Block Based Multimodal Anesthesia Versus Conventional Opioid Based Multimodal Anesthesia for Tonsillectomy Operations

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05513209

Enrollment

Registered

2022-08-24

Start date

2022-09-01

Completion date

2023-08-01

Last updated

2023-09-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

DECREASE POSTOPERATIVE HOSPITAL STAY, DECREASE POSTTONSILLECTOMY NAUSEA AND VOMITTING, PREVENTION OF POSTTONSILLECTOMY PAIN

Brief summary

intraoperative opioid administration versus intraoperative pterygopalatine ganglion block based opioid free anesthesia to compare outcomes such as postoperative administration of opioid rates of nausea and vomiting, Post Anesthesia Care Unit (PACU) length of stay

Detailed description

Group A ;( opioid based multimodal anesthesia) One hundred and twenty pediatric patients will do elective tonsillectomy or adenotonsillectomy surgery using opioid based multimodal anesthesia. Group B ;( opioid free pterygopalatine ganglion block based multimodal anesthesia) One hundred and twenty pediatric patients will do elective tonsillectomy or adenotonsillectomy surgery using opioid free pterygopalatine ganglion block based multimodal anesthesia. For each patient, intraoperative hemodynamics, additional intraoperative analgesia required, the length of PACU stay, administration of postoperative opioids, administration of postoperative non-opioid analgesics, postoperative (visual analogue score) VAS score, will be recorded.

Interventions

PROCEDUREopioid based multimodal anesthesia

elective tonsillectomy or adenotonsillectomy surgery using opioid based multimodal anesthesia.

PROCEDUREpterygopalatine ganglion block based multimodal anesthesia)

elective tonsillectomy or adenotonsillectomy surgery using opioid free pterygopalatine ganglion block based multimodal anesthesia.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

4 Years to 13 Years

Healthy volunteers

Inclusion criteria

* Age 4 to 13 years old. * Elective tonsillectomy or adenotonsillectomy surgery

Exclusion criteria

* Allergies to xylocaine. * Developmental delays. * Significant cognitive impairment. * American Society of Anesthesiologists (ASA) Class 3 and 4. * Patients who underwent any additional concurrent procedures such as lingual tonsillectomy.

Design outcomes

Primary

Measure	Time frame
postoperative VAS score	EVERY HOUR AFTER SURGERY FOR 24 HOURS

Secondary

Measure	Time frame
INTRAOPERATIVE HEART RATE	EVERY 10 MINUTES up to 1 hour
TOTAL AMOUNT OF GIVEN INTRAOPERATIVE OPIODS	DURING SURGERY
length of PACU stay	one day after operation
TOTAL AMOUNT OF OPIOD REQUIRED POSTOPERATIVELY	24 HOURS AFTER SURGERY
INTRAOPERATIVE BLOOD PRESSURE	EVERY 10 MINUTES up to 1 hour

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026