Menopause, Periodontal Diseases
Conditions
Brief summary
Menopause is characterized by major physiological and concomitant psychological changes. The study aimed to evaluate the association between oral health parameters, bone mineral density (BMD) and physiological or psychological symptoms in post-menopausal women (PMW), compared with regularly menstruating women (RMW). Inflammatory biomarker levels in gingival crevicular fluid, saliva, serum and determination of microbial niches in subgingival plaque samples were further aimed. The participants were asked to complete the Women's Health Questionnaire to measure emotional and physical well-being. A total of 148 women (PMW, n=76,RMW, n=72) received a comprehensive medical assessment and a full-mouth oral examination. The corresponding bone mineral density (BMD) and body mass indices (BMI) were obtained from their medical records.
Interventions
DIAGNOSTIC_TESTPeriodontal clinical examination and gingival crevicular fluid, saliva, dental plaque, serum sampling
Probing pocket depth was defined as the distance in millimeters from the gingival margin to the base of the gingival sulcus measured using a manual probe (Michigan 0 probe with Williams Markings) in all the teeth present except for third molars. Similarly, clinical attachment level (CAL) was measured as distance from cementoenamel junction to the base of pocket and recorded manually to the nearest millimeter marking on probe. 1 mililiter of saliva was obtained by each participant. Subgingival dental plaque was collected with sterile endodontic paperpoints from mesial sides of each natural teeth without a prostethic restoration. Gingival crevicular fluid samples were collected with absorbent paper strips. Serum samples were also collected at the time of visit.
Sponsors
Karolinska Institutet
Ege University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
35 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Being 35-65 years of age * Having history of spontaneous amenorrhea for the last 12 months for PMW. * Lack of irregularity in menstrual cycles during the past 12 months for RMPW. * Possessing at least 10 natural teeth without any prosthetic restoration
Exclusion criteria
* History of antibiotics use in last 3 months * Ongoing cancer therapy * Presence of oral ulcers or acute infectious disease * Presence of diabetes mellitus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Periodontitis | 1 month | Interdental attachment loss is detectable at ≥2 non-adjacent teeth, or buccal/oral attachment loss ≥3 mm with pocketing \>3 mm at ≥2 adjacent teeth were present. |
Countries
Turkey (Türkiye)
Outcome results
None listed