In-stent Restenosis and Pericoronary Fat Attenuation Index

Construction and Evaluation of Clinical Prediction Model of In-stent Restenosis After Percutaneous Coronary Intervention by Pericoronary Fat Attenuation Index and Radiomics Characteristics

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05512832

Enrollment

126

Registered

2022-08-23

Start date

2020-01-01

Completion date

2022-08-15

Last updated

2022-08-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

In-stent Restenosis

Keywords

pericoronary fat attenuation index

Brief summary

This study aims to investigate the predictive value of fat attenuation index (FAI) and related radiomics characteristics of pericoronary fat in patients after percutaneous coronary intervention (PCI) for the occurrence of in-stent restenosis (ISR) during the follow-up period (9 to 24 months). The results of this study are expected to provide an early assessment of the inflammation around the coronary lesion segment in patients after PCI, and provide a basis for early targeted intensive drug therapy in clinical practice.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Patients with coronary heart disease who have undergone PCI; * Patients followed up coronary angiography 9 to 24 months after PCI; * Patients received chest CT examination during inpatient/outpatient follow-up;

Exclusion criteria

* Patients with diseases of the immune system; * Patients with history of tumor diseases; * Patients with chronic/acute infectious diseases; * Image quality is not sufficient for analysis;

Design outcomes

Primary

Measure	Time frame	Description
Fat attenuation index (FAI)	2022.8.15-2023.8.14	The pericoronary FAI was defined as the mean CT attenuation of the pericoronary adipose tissue (-190 to -30 HU). Peri-stent FAI was measured around the stent segment of all 3 major epicardial coronary vessels.

Countries

China

Outcome results