Healthy
Conditions
Keywords
Prone positioning, high-flow nasal cannula, continuous positive airway pressure
Brief summary
Awake prone positioning (APP) has been proven to reduce the intubation rate for patients with COVID-19-induced hypoxemic respiratory failure. Our recent meta-analysis found APP was only effective for patients who were treated by high-flow nasal cannula (HFNC), not for patients using conventional oxygen therapy (COT).In a recent multicenter RCT, Perkins and colleagues reported that continuous positive airway pressure (CPAP) was superior to HFNC and conventional oxygen therapy in reducing intubation rate. Thus, it is essential to evaluate the physiological mechanism of APP under different respiratory supports, such as COT, HFNC, or CPAP. We hypothesize that HFNC or CPAP is more effective when combined with APP than COT combined with APP. Electrical impedance tomography (EIT imaging) has been broadly utilized to assess patient ventilation homogeneity and respiratory volume monitor (RVM) has been used to evaluate patient's tidal volumes breath-by-breath. In this study, 20 healthy volunteers will use different respiratory support devices (HFNC, CPAP, and COT) in different settings and their combinations withAPP in a random sequence, assessed by EIT and RVM.
Detailed description
Awake prone positioning (APP) has been proven to reduce the intubation rate for patients with COVID-19-induced hypoxemic respiratory failure. Our recent meta-analysis found APP was only effective for patients who were treated by high-flow nasal cannula (HFNC), not for patients using conventional oxygen therapy (COT).In a recent multicenter RCT, Perkins and colleagues reported that continuous positive airway pressure (CPAP) was superior to HFNC and conventional oxygen therapy in reducing intubation rate. Thus, it is essential to evaluate the physiological mechanism of APP under different respiratory supports, such as COT, HFNC, or CPAP.
Interventions
OTHERawake prone positioning with advanced respiratory support (high-flow nasal cannula or continuous positive airway pressure)
in this group, healthy subjects will stay in prone position for 20 mins with respiratory support of high-flow nasal cannula or CPAP
Sponsors
Rush University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
healthy adults aged between 21 to 65 years
Exclusion criteria
* Tested COVID positive within 21 days, or has any of the following symptoms in the last 21 days: sore throat, cough, chills, body aches for unknown reasons, shortness of breath for unknown reasons, loss of smell, loss of taste, fever at or greater than 100 degrees Fahrenheit. * Currently have the following symptoms: sore throat, fever, coughing, shortness of breath, loss of smell or taste * Non-English speaking * Has any of the following diseases: asthma, chronic obstructive pulmonary disease, Uncontrolled Diabetes, hypertension, or untreated thyroid disease * and spinal cord injury. * Claustrophobia * Pregnancy * Pacemaker (EIT contraindication) * face or chest skin injury that could not use a facemask or the electrode belt * could not tolerate prone positioning for one hour
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ventilation distribution assessed by EIT | 20 minutes | Regional ventilation assessed by regional tidal impedance variations relative to global tidal impedance variation (ΔzROI/Δzglobal) obtained by electrical impedance tomography (EIT) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| tidal volume | 20 minutes | the gas volume during tidal breathing |
| respiratory rates | 20 minutes | breathing frequency during tidal breathing |
| comfort | 20 minutes | subject's comfort which will be assessed by a 1-10 scale |
Countries
United States
Outcome results
None listed