Cervical Cancer, Radiotherapy Side Effect
Conditions
Keywords
Radiosensitivity, Circadian rhythm
Brief summary
The study was a Randomized Clinical Trial (RCT) or clinical trial comparing the results of radiation treatment of 2 treatment groups, i.e. subject groups irradiated in the morning and in the afternoon, to check melatonin levels in cervical cancer patients. Since it is known that the function of melatonin is as an antiproliferation substance or hormone, induces apoptosis, inhibits invasion and metastasis.
Interventions
RADIATIONAfternoon Radiation
Melatonin, a hormone of the pineal gland, which levels are characteristic of circadian patterns, regulated with low levels of excretion in the afternoon, rises gradually during the night, peaks at dawn, and falls back in the afternoon and late afternoon. Many studies prove the function and potential of melatonin as circadian biomarkers and well correlated with the development of cancer.The function of melatonin is as an antiproliferation substance or hormone, induces apoptosis, inhibits invasion and metastasis.
Sponsors
Indonesia University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Caregiver)
Eligibility
Sex/Gender
ALL
Age
25 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* cervical cancer patients stage IIB-IIIB (FIGO) * no previous treatment * histopathologic examination results of squamous cell carcinoma (SCC) * KPS \> 70 with levels of Hb \> 10 g%,
Exclusion criteria
* Distant metastasis and locally spread to the adjacent healthy tissue (urinary bladder or rectum).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Radiation response | Four weeks after the completion of radiation | We assessed the change in tumor size between the initial examination and the fourth week after the completion of irradiation, to classify the tumor response based on the modified WHO criteria which categorized as good response or poor response. |
Outcome results
None listed