Acute Myocardial Infarction, New Onset Atrial Fibrillation
Conditions
Keywords
myocardial infarction, new-onset atrial fibrillation, atrial fibrillation burden, mortality
Brief summary
To investigate the prognostic impacts of the atrial fibrillation burden (AFb) in acute myocardial infarction (AMI) patients who developed paroxysmal new-onset atrial fibrillation (NOAF) during the index AMI hospitalization.
Detailed description
In the present study, investigators retrospectively reviewed the medical records of all acute MI patients who were admitted to the coronary artery unit (CCU) of Shanghai Tenth People's Hospital, KaiFeng Central Hospital, and the First Affiliated Hospital of Zhengzhou University between January 2014 and January 2022. All patients will routinely receive continuous electronic monitoring (CEM) throughout their hospital stay to detect cardiac arrhythmias including the AF events. Of these, patients with AMI without a history of AF who developed a first documented AF episode will be considered for inclusion. The AFb is measured as a percentage (%) by dividing the total AF duration by the total CEM duration.
Interventions
All patients with MI hospitalized in the CCU department of Shanghai Tenth People's Hospital, KaiFeng Central Hospital, and the First Affiliated Hospital of Zhengzhou University will receive 24-hour continuous cardiac monitoring until discharge.
Sponsors
Shanghai 10th People's Hospital
Kaifeng Central Hospital
The First Affiliated Hospital of Zhengzhou University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients hospitalized for AMI including both STEMI and NSTEMI between January 2014 and January 2022 at the CCU department of Shanghai Tenth People's Hospital, KaiFeng Central Hospital, and the First Affiliated Hospital of Zhengzhou University. 2. Patients who developed a first documented AF (NOAF) during the index AMI hospitalization； 3. Adult patients (\>18 years old).
Exclusion criteria
1. Patients with a medical history of pre-existing AF; 2. Patients with a medical history of rheumatic valvular disease; 3. Patients with a medical history of sick sinus syndrome; 4. Patients undergoing emergent coronary artery bypass surgery; 5. Patients' medical records with serious deficiencies and CEM data cannot be retrieved;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| All-cause death | From the time of AMI discharge until occurrence of an outcome of interest, death, or loss to follow up, maximum up to 10 years | Death from any cause |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Major bleeding | From the time of AMI discharge until occurrence of an outcome of interest, death, or loss to follow up, maximum up to 10 years | Bleeding event with a Bleeding Academic Research Consortium (BARC) classification of types 3 or 5. |
| Cardiovascular death | From the time of AMI discharge until occurrence of an outcome of interest, death, or loss to follow up, maximum up to 10 years | Death from cardiovascular causes |
| Recurrent myocardial infarction | From the time of AMI discharge until occurrence of an outcome of interest, death, or loss to follow up, maximum up to 10 years | Rehospitalization for myocardial infarction |
| Heart failure hospitalization | From the time of AMI discharge until occurrence of an outcome of interest, death, or loss to follow up, maximum up to 10 years | HF hospitalization was based on clinical symptoms such as dyspnea and fatigue, and signs of peripheral or pulmonary edema that required hospitalization for intravenous diuretic treatment |
| Ischemic stroke | From the time of AMI discharge until occurrence of an outcome of interest, death, or loss to follow up, maximum up to 10 years | Ischemic stroke was identified as the presence of a new focal neurologic deficit thought to be ischemic in origin, with signs or symptoms lasting\> 24 hours, and was validated according to radiographic imaging test. |
Countries
China
Contacts
PRINCIPAL_INVESTIGATORYidong Wei, M.D., Ph.D.
Shanghai 10th People's Hospital
Outcome results
None listed