Parkinson Disease
Conditions
Keywords
Parkinson Disease, exercise, total antioxidant status, total oxidant status, glutathione, oxidative glutathione, zonulin
Brief summary
Parkinson's disease is a chronic, neurodegenerative disorder characterized with the loss of dopamine-producing neurons. This loss is likely to be related with several environmental and genetic factors. One of the most important factor that is responsible for the initation and progression of the disease is oxidative stress. Exercise training, especially aerobic training, can change the levels of oxidative markers because exercise can lead to decrease oxidative stress in patients with Parkinson's disease. Therefore, this study aims to investigate (1) the effect of aerobic training on total antioxidant status, total oxidant status, glutathione, oxidative glutathione, and zonulin levels, (2) the relationship between the change of motor symptoms and disease severity and the change of total antioxidant status, total oxidant status, glutathione, oxidative glutathione, and zonulin levels.
Interventions
OTHERExercise training
People with Parkinson's Disease will be received a supervised physiotherapy and rehabilitation program.
Sponsors
Gazi University
Saglik Bilimleri Universitesi
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* at least 40years of age * diagnosed with Parkinson's Disease * Hoehn and Yahr stage of 1 and 3
Exclusion criteria
* any other neurologic disorders, * any cardiovascular, orthopedic, vestibular or rheumatic conditions that impact exercise training * visual, auditory, and perception problems.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total antioxidant status | 10 minutes | Total antioxidant status is an important marker of total antioxidant capacity and it indicates an overall measure for the cumulative action of all antioxidants. |
| Total oxidant status | 10 minutes | Total oxidant status is an significant marker of total oxidant capacity and it indicates an overall measure for the cumulative action of all oxidants. |
| Glutathione | 10 minutes | Glutathione is an important intracellular antioxidant that protects against a variety of different antioxidant species. |
| Oxidative glutathione | 10 minutes | Oxidative glutathione generated by glutathione reductase should be provided as decreased glutathione to the site. |
| Zonulin | 10 minutes | The levels of zonulin can reflect systemic inflammation and oxidative stress. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Movement Disorders Society Unified Parkinson's Disease Rating Scale | 15 minutes | The Movement Disorders Society Unified Parkinson's Disease Rating Scale is the most commonly used scale to assess disease severity in Parkinson's Disease. It consists of four parts: (1) non-motor experiences of daily living, (2) motor experiences of daily living, (3) motor examination, and (4) motor complications. |
Countries
Turkey (Türkiye)
Contacts
Primary ContactFatih Soke, Asst. Prof.
Outcome results
None listed