Gastric Cancer, Gastritis, Intestinal Cancer, Intestine Adenoma
Conditions
Keywords
Gastroscopy, High-flow nasal oxygenation, Hypoxia, High-risk, Colonoscopy
Brief summary
The objective of this study is to observe the preventive effects of high flow nasal oxygenation on the incidence of hypoxia during gastroscopy or colonoscopy sedated with propofol in high-risk patients.
Interventions
The patients receive oxygen flow of 6L/min for preoxygenation with an high-flow canular oxygenation device before losing of conscious. Then, the oxygen flow is adjusted to 60L/min with the oxygen concentration of 100% and the temperature of 37℃ until the end of procedure.
DEVICERegular nasal cannula oxygenation
The patients receive an oxygen flow of 6L/min for preoxygenation with a disposal regular nasal cannula until the end of procedure.
Sponsors
RenJi Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Age ranging from 18 to 80, both sexes 2. Patients receiving selective gastroscopy or colonoscopy or gastroscopy and colonoscopy procedure 3. ASA Ⅲ\ Ⅳ 4. 18 kg/m2\<BMI\<28kg/m2 5. The anticipated operation time of the procedure shall be less than 30min. 6. Patients should clearly understand and voluntarily participate in the study, with signed informed consent.
Exclusion criteria
1. Patients with nasal congestion, epistaxis, recent nasal trauma, recent nasal surgery, increased intracranial pressure and skull fracture, etc. who can not tolerate high-flow nasal cannula. 2. Patients diagnosed POCD 3. Patients clearly identified difficult airway 4. Patients with mechanical ventilation 5. Patients with acute respiratory infection and asthma 6. Patients with acute upper gastrointestinal hemorrhage accompanied by shock, severe anemia, gastrointestinal obstruction accompanied by retention of gastric contents 7. Patients with aortic stenosis and carotid stenosis 8. Patients allergic to sedatives such as propofol 9. Patients without civil capacity such as cognitive dysfunction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of hypoxia | Patients will be followed for the duration of hospital stay, an expected average of 2 hours | Hypoxia refers to 75%≤SpO2\<90%,\<60S |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of severe hypoxia | Patients will be followed for the duration of hospital stay, an expected average of 2 hours | Severe hypoxia refers to SpO2\<75% lasting for any time, or 75%≤SpO2\<90%, ≥60s |
| The incidence of subclinical respiratory depression | Patients will be followed for the duration of hospital stay, an expected average of 2 hours | Subclinical respiratory depression refers to 90%≤ SpO2\<95% |
| Other adverse events evaluated by the tool of World SIVA | Patients will be followed for the duration of hospital stay, an expected average of 2 hours | — |
| Complications related to high-flow nasal cannula | Patients will be followed for the duration of hospital stay, an expected average of 2 hours | — |
Countries
China
Contacts
Primary ContactWanfeng Liu
Outcome results
None listed