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Precision Antimicrobial STewardship for Clostridioides DIfficile Prevention

Precision Antimicrobial STewardship for Clostridioides DIfficile Prevention

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05508607
Acronym
PASTCDI
Enrollment
13319
Registered
2022-08-19
Start date
2021-05-01
Completion date
2022-06-30
Last updated
2022-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CDI

Brief summary

To decrease CDI incidence by implementing an electronic health record-integrated CDI-risk classification tool for Clostridioides difficile infection (CDI) to focus a bundle of antimicrobial stewardship (AMS) CDI prevention recommendations on high-risk patients.

Detailed description

This study aims to use a pre/post implementation design to evaluate the use of a novel risk classification tool to improve existing methods of identifying patients eligible for routine antimicrobial stewardship (AMS) care processes targeting reduction of Clostridioides difficile infection (CDI). Antimicrobial stewardship is an established, evidence-based quality improvement program that is required by The Joint Commission and a condition of participation by the Centers for Medicare and Medicaid. AMS processes of care are evidence based, supported by published research demonstrating outcomes benefits, are recommended by national guidelines and are not investigational. Treatment decisions remain at the discretion of clinicians and patients

Interventions

OTHERCDI-risk Classification Tool

This tool will focus a bundle of antimicrobial stewardship (AMS) CDI prevention recommendations on high-risk patients.

Sponsors

Intermountain Health Care, Inc.
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum

Inclusion criteria

* adult acute care patients identified as high-CDI risk by the CDI risk classification tool. This sub-group represents approximately 6% of all acute care admissions

Exclusion criteria

* Behavioral health units * Inpatient rehabilitation units * Labor and Delivery units * Same day surgery and observation units

Design outcomes

Primary

MeasureTime frameDescription
Per-Admission Rate30 days after dischargeper-admission rate of hospital-associated CDI, defined as: positive toxin B by enzyme-linked immunoassay or polymerase chain reaction test at least 72 hours after admission

Secondary

MeasureTime frame
Total Antibiotic Usagethrough study completion, an average of 1 year
High-Risk Antibiotic Usagethrough study completion, an average of 1 year
Proton Pump Inhibitor Therapy Administeredthrough study completion, an average of 1 year
Total Variable Cost per Admissionthrough study completion, an average of 1 year
Hospital Length of Staythrough study completion, an average of 1 year

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026