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Protein and Satiety in Older Adults (PROSAT)

The Effect of Protein on Appetite and Food Intake in More and Less Active Older Adults.

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05507801
Enrollment
38
Registered
2022-08-19
Start date
2021-11-19
Completion date
2022-08-23
Last updated
2024-06-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Appetitive Behavior, Energy Intake, Gastric Emptying, Physical Activity

Keywords

protein, physical activity, older adults, appetite, energy intake, satiety

Brief summary

This study aims to assess the effect of protein on appetite, food intake and gastric emptying in older adults (≥ 65 years) that are more and less active.

Detailed description

To investigate the differences in food intake in older adults that are more or less active and assess any differential responses to protein intake. To compare the effect of meals with high or low protein level but equal in energy and volume on appetite and gastric emptying in older adults that are more or less active (≥ 65 years).

Interventions

OTHERHigh Protein Milkshake

A milkshake with high protein level; including whey protein, fat free strawberry yogurt and whole milk - 337 kcal, 27 g carbohydrate, 57 g protein, 16 g fat.

OTHERNormal Milkshake

A milkshake with normal protein level; including nesquik (strawberry), fat free strawberry yogurt, whole milk, double cream, whey protein and sweetener - 331 kcal, 64 g carbohydrate, 17 g protein, 19 g fat.

Sponsors

Ministry of National Education, Turkey
CollaboratorOTHER_GOV
University of Reading
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Subject)

Masking description

Single (Participants)

Eligibility

Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* healthy * aged ≥ 65 years

Exclusion criteria

* having diabetes or disability or any disease that are likely to influence physical activity or appetite. * having an allergy to any of the test foods; * disliking or cannot eat any of the test foods; * being obese (BMI \> 30 kg/m2); * taking medications known to influence appetite, food intake or body weight in the past three months; * being on a weight loss diet; * smoking more than 10 cigarettes a day; * not meeting the cut-off point criteria based on the accelerometer data (108.25 ≤ min/per day of moderate and vigorous activity for women or 162 ≥ min/per day moderate and vigorous activity for women and 100.1 ≤ min/per day of moderate and vigorous activity for men or 133.25 ≥ min/per day moderate and vigorous activity for men).

Design outcomes

Primary

MeasureTime frameDescription
Ad-libitum meal consumption2 days in totalConsumption of the ad-libitum meal is measured (g). Participants are instructed to eat until they feel comfortable full and are given 20 min to consume the meal.

Secondary

MeasureTime frameDescription
Ratings of appetite2 days in totalAppetite are assessed using a 100 mm Visual Analogue Scales (VAS, scale 0-100).
Gastric Emptying2 days in totalGastric emptying is measured using of 100 microliters of 13C Octanoic Acid breath test
Ratings of palatability2 days in totalPalatability ratings are assessed using a 100 mm Visual Analogue Scales (VAS, scale 0-100).

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026