Investigating STAT3 as a Driver of Pathology in Periodontitis

Investigating STAT3 as a Driver of Pathology and Potential Therapeutic Target in Periodontitis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05506098

Enrollment

Registered

2022-08-18

Start date

2019-03-20

Completion date

2022-10-20

Last updated

2023-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Keywords

periodontitis, STAT3

Brief summary

Periodontitis is a prevalent inflammatory condition that destroys tooth-supporting structures. This condition is associated with pro-inflammatory mediators that utilize STAT3 as an activator of specific genes related to inflammation and tissue destruction. STAT3 has not been studied in the context of periodontitis in humans. We propose that STAT3 is associated with periodontitis. This knowledge might help to further our understanding of periodontitis pathology

Interventions

OTHERno intervention

no intervention

Study design

Observational model

OTHER

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* 18-year-old, in good general health, and had no significant medical history. * no history of diabetes or other diseases different than periodontitis.

Exclusion criteria

* Pregnancy and lactation * Use of antibiotics, immunosuppressive agents, or probiotics within 3 months.

Design outcomes

Primary

Measure	Time frame	Description
STAT3 detection in gingival tissues	1 day	Detection of STAT3 in gingival tissues

Countries

Chile

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026