Effects of Postoperative Analgesic Modalities on Plasma Creatine Phosphokinase(CPK) Levels After Knee Artroplasty

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05505890

Enrollment

Registered

2022-08-18

Start date

2022-12-16

Completion date

2023-02-21

Last updated

2023-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myotoxicity

Keywords

bupivacaine, myotoxicity, creatine phosphokinase,SFIPB

Brief summary

Regional anesthesia and analgesia technics are widely and securely used during orthopedic surgery. Interfascial plane blocks are the latest used ones for analgesia. There are studies in literature indicating that bupivacaine cause myotoxicity. We aimed to examine plasma CPK(creatine phosphokinase) levels to see whether myotoxicity occurs or not after suprainguinal fascial plane block is applied to patients undergoing knee artroplasty surgery.

Detailed description

During 2 months period all elligible patients undergoing knee artoplasty surgery will be included in the study. Different postoperative analgesic modalities will be used according to the anesthesists experience. During routine blood sample tests plasma CPK levels will be tested 3 times of all patients.(preoperative, postoperative 6th hour, postoperative 24th hour) this data will be recorded for 2 months. After this period of time data will be analysed and patients will be grouped according to the analgesic modalities used.

Interventions

OTHERsuprainguinal fascia iliaca block

Suprainguinal fascia iliaca block will be performed after the end of surgery for postoperative analgesia.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* ASA 1-3 * knee artoplasty patients * under spinal anesthesia

Exclusion criteria

* local anesthetic allergies * myopathies * coagulopathies * Obstructive sleep apne syndrome * hearth diseases * liver diseases * kidney diseases * thyroid-parathyriod dieseas * hiperlipidemias using Statins(HMG-CoA reductase inhibitors) * pregnancy

Design outcomes

Primary

Measure	Time frame	Description
CPK levels	at postoperative 24th hour	Change from Baseline serum creatine phosphokinase at 24 hours

Secondary

Measure	Time frame	Description
Number of patients requesting rescue analgesics	up to 24 hours	Intravenous administration of meperidine 25 mg as a rescue analgesic is planned for patients who complain of severe pain despite multimodal analgesia.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026