Acute Brain Injury, Hyperglycemia, Hyperlactatemia
Conditions
Brief summary
This is an observational study of patients with severe acute brain injury, which aims to characterize the development of hyperglycaemia and hyperlactataemia and the influence of these markers on clinical outcome. Additionally, in a subgroup of patients undergoing advanced multimodal neuromonitoring on either clinical or research indication, the relationship between hyperglycaemia and brain glucose levels as well as systemic and microdialysis lactate will be examined.
Interventions
Blood HbA1c, insulin, C-peptide and IL-6 measured at admission. Glucose and lactate measured every 4 hours during intensive care stay. Daily sampling of CSV analysed for glucose and lactate in patients with EVD.
Sponsors
Rigshospitalet, Denmark
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Age ≥ 18 years * Admission to the neurointensive care unit at Rigshospitalet * Diagnosis of acute brain injury categorised as TBI, SAH, ICH, ischaemic stroke, or other conditions
Exclusion criteria
* Brain death before inclusion * Closest relatives do not understand written and spoken Danish or English
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Functional outcome at 6 months as evaluated by the modified Rankin Scale. | 6 months after admission. | Modified Rankin Scale ranges from 0-6, where 0 is the best and 6 is the worst outcome. |
Secondary
| Measure | Time frame |
|---|---|
| All-cause mortality at 6 months (dichotomous). | 6 months after admission. |
| Length of stay in the neuro-ICU (continuous). | Day of discharge, typically 1-30 days after admission. |
Countries
Denmark
Outcome results
None listed