Pulse Pressure Variation Based Intraoperative Fluid Management Versus Traditional Fluid Management for Colonic Cancer Patients Undergoing Mass Resection and Anastomosis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05502835

Enrollment

Registered

2022-08-16

Start date

2022-08-20

Completion date

2023-01-25

Last updated

2023-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

First Time to Gastrointestinal Motion, Hemodynamics, Intestinal Edema, Intraoperative Fluid Volume, Length of the Hospital Stay, Postoperative Complications, Serum Lactate

Brief summary

pulse pressure variation based intraoperative fluid therapy versus traditional fluid therapy for colonic cancer patients undergoing mass resection and anastomosis for maintaining adequate hydration without complications.

Detailed description

All Patients will be assigned randomly by using computerized program to one of the two equal groups. Patients will be (forty five patients per group): Group A ;( control group) Forty five patients will do elective open colonic mass resection and anastomosis. Infusion of 6 ml/kg/hr. Ringer's solution. Group B; Forty five patients will do elective open colonic mass resection and anastomosis. Infusion of 2 ml/kg/hr. Ringer's solution guided by pulse pressure variation. Intraoperative fluid volume, hemodynamics, serum lactate and intestinal edema will be measured after induction of anesthesia and every hour till the end of the operation, length of the hospital stay, first time to gastrointestinal motion and postoperative complications are recorded.

Interventions

DEVICEpulse pressure variation

Infusion of 2 ml/kg/hr. Ringer's solution guided by pulse pressure variation.

OTHERconventional fluid management

Infusion of 6 ml/kg/hr. Ringer's solution.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* American Society of Anesthesiologists physical status (ASA-PS) I and II Patients. * Patients scheduled for elective open colonic mass resection and anastomosis.

Exclusion criteria

* Serious cardiac arrhythmia. * Peripheral artery disease. * An ejection fraction below 30%. * A pulmonary pathology.

Design outcomes

Primary

Measure	Time frame
Intraoperative fluid volume	calculated immediately after surgery

Secondary

Measure	Time frame
intraoperative blood pressure	every ten minutes till the end of the surgery
lactate level	every hour till the end of the surgery
POSTOPERATIVE COMPLICATIONS	till one week after surgery
intestinal oedema	intraoperatively after tumor resection

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026