Acquired Brain Injury, Cerebrovascular Accident, Subarachnoid Hemorrhage, Traumatic Brain Injury
Conditions
Brief summary
A prospective cohort study (questionnaires), with an embedded case control study (neuropsychological assessments) in which the data is gathered within a timeframe of 3 years. A group of 700 patients and a group of 100 healthy volunteers will be participating.
Detailed description
In the Netherlands an estimated 650.000 people live with the daily consequences of an Acquired Brain Injury (ABI). A substantial amount of these patients acquired their brain injury (traumatic brain injury, subarachnoid hemorrhage or cerebrovascular accident) at a relatively young age: between 18 and 50 years old. The chain-of-care for ABI aims for recovery in the subacute phase, usually within a period of one year after injury. After an adaptation period, the patients reach a new balance, with stabilization of complaints and reintegration, sometimes with the necessity of modifications. The group of patients who acquired a brain injury at a young age, have to face the effects of aging like decreased cognitive functions, which can cause the participation level to drop. This is called the ABI-effect in the current study. At this moment, insufficient information is available about the functioning of people who suffered ABI multiple years ago and have established a new balance, and now make the transition to an older phase of live. Primary objective: Explore the prevalence of the ABI-effect, by mapping the participation level. Secondary objective: Substantiate the occurence of the ABI-effect, by mapping cognitive functions of patients and compare these to healthy controls. Tertiary objective: Gain insight in the need of care for patients, to enhance regular care after ABI.
Interventions
None listed
Sponsors
ZonMw: The Netherlands Organisation for Health Research and Development
University Medical Center Groningen
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
50 Years to 67 Years
Healthy volunteers
Yes
Inclusion criteria
* Current age range between 50-67 years \[Rationale: having an age that enables the patient to experience the effects of aging with a low risk of neurodegenerative disease\] * Able to complete questionnaires independently Additionally, patients must also meet the following criteria: * Age of acquiring the ABI ≧ 25 years \[Rationale: the brain is supposed to be fully developed at a maximum capacity * ABI must be ≧ 5 years ago\] \[Rationale :time period regarded sufficient to have achieved a stable level of cognitive functioning and participation after an ABI\] * ABI diagnosis at hospital admission with abnormalities at the brain-CT or MRI * Independent regarding Activities of Daily Living * Not living in a long-term care facility
Exclusion criteria
* Psychiatric disease (for which participant is currently treated) * Accompanying disease with reduced life expectancy * Neurological disease (including recurrent ABI for patients) * Language barriers prohibiting and completion of Dutch questionnaires * Alcohol or drug abuse * Suspected neurodegenerative disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of the ABI-effect | A minimum of 5 years after ABI | The percentage of patients experiencing the ABI-effect. Also, a 95% confidence interval of this prevalence will be calculated. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive functions of patients and healthy volunteers | A minimum of 5 years after ABI for patients | The significant difference in cognitive functions between the patient groep and the healthy controls |
Countries
Netherlands
Outcome results
None listed