Glaucoma, Open-Angle
Conditions
Keywords
Glaucoma, Methazolamide, Primary Open Angle Glaucoma
Brief summary
The purpose of this study is to evaluate the effect of methazolamide, 25 mg or 50 mg tablets once a day for a week than twice a day for a week, on lowering intraocular pressure and the safety of methazolamide.
Interventions
DRUGMethazolamide 25 MG
25 mg tablets
DRUGMethazolamide 50 MG
50 mg tablets
Sponsors
University of Colorado, Denver
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
Double
Eligibility
Sex/Gender
ALL
Age
50 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Males and females between 50 and 90 years old * Current diagnosis of open angle glaucoma (OAG) in both eyes * Ability to read and write in English
Exclusion criteria
* Glaucoma other than OAG * Severe or end-stage glaucoma (cup to disc ratio \>0.8 or Mean Deviation on Visual Field worse than -12) * Pregnant or breast-feeding women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percent IOP change at each follow-up Visit | Day 1 (Pre-dosing, then 4- and 8- hours post dosing), Day 7 (Pre-dosing, then 4- and 8- hours post dosing), Day 14 (Pre-dosing, then 4- and 8- hours post dosing) | IOP measure is measured using Goldmann Tonometry. IOP is measured in mmHg with a normal range from 12 mmHg to 22 mmHg. |
Countries
United States
Outcome results
None listed