Premature
Conditions
Brief summary
The aim of this work to study the hemodynamic changes accompanying anemia of prematurity in neonates with gestational age ≤32 weeks and the effect of its treatment on hemodynamics.
Detailed description
This prospective observational study aims to evaluate the hemodynamic changes provoked by anemia of prematurity and transfusion of packed red blood cells (RBCs). Nonanemic inpatient premature infants (Hematocrit\>30%) will be compared with pretransfusional anemic inpatient premature infants. Anemic premature infants will be assessed before and 24 hours after the transfusion of pRBCs. Cerebral, intestinal and renal blood flow velocities, cardiac output parameters will be measured in premature neonates who will fulfill the eligibility criteria of the study.This study will be conducted at the neonatal intensive care units in Alexandria University Hospitals.
Interventions
RADIATIONEchocardiographic and Doppler studies
Echographic and Doppler studies will be performed using machine: model GE Vivid iq premium,WUXI,China and we will measure: 1. Cardiac output: 2. Cerebral, intestinal and renal blood flow velocities:
Sponsors
Marwa Mohamed Farag
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Weeks to 6 Weeks
Healthy volunteers
Yes
Inclusion criteria
* Preterm infants ≤32 weeks gestational age, regardless their weight with postnatal age 3-6 weeks.
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 1. Cardiac output: | 3-6 weeks postnatal age | Probe: GE 12S-RS probe with a frequency range of 5 - 11 MHz. Cardiac output as the product of stroke volume and heart rate: actual body weight in mL/kg/min; Stroke volume (the product of velocity time integral at the level of aortic valve pulsed wave (PW) and cross-sectional area of the left ventricular outflow tract at the level of aortic valve using 2D.( |
| 2. Cerebral blood flow velocities | 3-6 weeks postnatal age | in the anterior cerebral artery through the anterior fontanelle in the sagittal plane |
| 3. Intestinal blood flow velocities | 3-6 weeks postnatal age | in the celiac artery from a longitudinal abdominal section, determined close to the origin of the artery from the abdominal aorta. |
| 4.Renal blood flow velocities | 3-6 weeks postnatal age | Renal blood flow velocities in the right renal artery by placing the transducer below the right costal arch in the dorsolateral area of the flank in longitudinal axis. |
Countries
Egypt
Outcome results
None listed