Physical Fitness, Pulmonary Function, β-Thalassemia
Conditions
Brief summary
The aims of this study are: 1. To determine the correlation between pulmonary functions and physical fitness in children with β-thalassemia. 2. To differentiate between different types of B-thalassemia in both pulmonary functions and physical fitness
Detailed description
Cohort study: cross-sectional design A) Subjects: Sample size estimation will be carried out to determine the recruited number of children selected randomly. Each participant's caregiver will sign a consent form authorizing the participation of their children in this study. They will be selected based on the following: Inclusion criteria: * age range from 6 to 12 years * children with β-thalassemia major and intermediate of both sex and control healthy children of both sex * They can follow instruction Exclusive criteria: Children will be excluded from the study if they have: * Defined Cardiovascular or respiratory disorders. * Renal failure * Visual or hearing impairment, Mentally retarded children * Myocardial infarction within the last month * Unstable angina, Recent thoraco-abdominal surgery * Thoracic or abdominal aneurysm or Current pneumothorax II) Materials 1. For evaluation of pulmonary functions The measurements that are made include forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and the ratio of the two volumes (FEV1/FVC). 2. For evaluation of physical fitness Aerobic capacity and endurance By 6-Minute Walk Test , 3 minutes step test and Energy expenditure BMI Balance Pediatric balance scale
Interventions
OTHERno intervention
NO intervention
Sponsors
Cairo University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
6 Years to 12 Years
Healthy volunteers
Yes
Inclusion criteria
* • age range from 6 to 12 years * children with β-thalassemia major and intermediate of both sex and control healthy children of both sex * They can follow instruction
Exclusion criteria
* • Defined Cardiovascular or respiratory disorders. * Renal failure * Visual or hearing impairment, Mentally retarded children * Myocardial infarction within the last month * Unstable angina, Recent thoraco-abdominal surgery * Thoracic or abdominal aneurysm or Current pneumothorax
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| assessment of pulmonary functions by spirometer | baseline - one hour for each participant | measurements difference in vital capacity and minute ventilation |
| physical fitness | baseline - one hour for each participant | functional capacity by 6 minute walk test |
| cardiorespiratory fitness | baseline - one hour for each participant | measure by 3 minutes step test to monitor recovery of heart rate after stress test |
Countries
Egypt
Contacts
Primary Contactesraa elsayed
Backup Contactsheref abdelhai
Outcome results
None listed