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Autologous Blood for Full-thickness Macular Hole

Autologous Whole Blood for Closing Full-thickness Macular Hole

Status
Terminated
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05494229
Enrollment
5
Registered
2022-08-09
Start date
2022-09-01
Completion date
2023-03-01
Last updated
2023-03-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ophthalmopathy

Keywords

Full Thickness Macular Hole, Blood Clot, Whole blood, Pars-pana vitrectomy

Brief summary

Autologous blood for primary and recurrent holes

Detailed description

Utilizing whole autologous blood for closing both primary and recurrent holes. Here, we apply a drop of the taken whole blood over the hole, and the access blood will be aspirated on the macula with a silicon-tipped active back-flash cannula, to abolish all the possibilities of the fibrinogenic behavior of the whole blood composition, which might cause traction and recurrent hole formation. Therefore, only the hole will be filled with blood. The blood will be taken under completely sterile and aseptic conditions. The air infusion will be raised after the valve of one of the trocars will be removed, to allow the air current to dry the clot inside the hole rapidly. Then air gas exchange will be performed to allow the clot to remain away from intraocular fluids for one to two weeks and abolish the possibility of the clot being dissolved.

Interventions

OTHERPars-plana vitrectomy

Pars-plana vitrectomy

Sponsors

Omer Othman Abdullah
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* Primary and recurrent holes

Exclusion criteria

* Lamellar and pseudoholes

Design outcomes

Primary

MeasureTime frameDescription
Anatomical outcomeThe fourth week post-operativelyOCT

Secondary

MeasureTime frameDescription
Functional outcomeThe fourth week post-operatively.Best corrected visual acuity

Countries

Iraq

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026