Obesity
Conditions
Brief summary
The purpose of this study is to establish a prospective cohort. From registration to the 5th year, basic investigation, specific examinations for cardiovascular and metabolic disease, basic blood tests, collection of human material samples, and clinical event follow-up are conducted yearly. The obese group will be examined yearly, and telephone follow-up will be conducted if necessary. The control group will participate in the baseline survey once enrollment and clinical event follow-up by phone will be conducted annually thereafter. From the 6th year, only clinical event follow-up will be conducted.
Detailed description
The obese group will enroll 500 people within 1 year of study initiation and follow-up annually. The control group will enroll 30 patients a year for 5 years.
Interventions
None listed
Sponsors
Yonsei University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
for the obese group 1. Adults 19 years of age or older 2. Obese patients with chronic diseases such as cardiovascular disease, hypertension, diabetes, and metabolic syndrome (BMI ≥ 25 kg/m2, \[BMI ≥ 30 kg/m2, including 10% or more\]) Inclusion criteria for the control group 1. Adults 19 years of age or older 2. Those with BMI 18.5\ 24.9 kg/m2
Exclusion criteria
for the obese group 1. Serious non-cardiovascular disease with life expectancy less than 6 months 2. Pregnant or suspected of being pregnant or are lactating 3. Patients within 3 months of organ transplantation 4. Patients currently being treated for acute transplant rejection 5. Patients treated for acute coronary syndrome (myocardial infarction, unstable angina) and discharged within 6 months 6. Patients with acute cerebral infarction within 6 months of being hospitalized and discharged 7. Type 1 Diabetes 8. Patients taking steroids, female hormones 9. Those who have difficulty using smartphones
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences of nutriomics according to obesity phenotypes | At five years of study | Cross-sectional analysis of nutriomics of normal control group and obese patients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical events | three years, four years, five years, etc | A composite of all-cause mortality, cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke, revascularization of coronary artery, and heart failure hospitalization |
Countries
South Korea
Contacts
Primary ContactSungha Park
Outcome results
None listed