Helicobacter Pylori Infection
Conditions
Brief summary
The patients who accepted the quadruple eradication program of the helicobacter pylori but failed to eradicate helicobacter pylori will be assessed the most suitable re-eradication time of helicobacter pylori.
Detailed description
Helicobacter pylori (HP) infection is a common global infectious disease, which is an important cause of chronic gastritis, peptic ulcer and gastric cancer. At present, due to the non-standard Helicobacter pylori eradication program in clinical work, poor patient compliance and other reasons, the phenomenon of HP eradication treatment failure is more and more common. However, there is still no conclusion on the most appropriate time for remedial treatment inpatients with Hp eradication failure.
Interventions
Remedial therapy was performed within 3 months
Remedial therapy was performed within 3 to 6 months
Remedial therapy was performed within 6 to 12 months
Remedial therapy was performed after 12 months
Sponsors
Shandong University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged 18-70 with H. pylori infection. * Patients with previous Helicobacter pylori eradication.
Exclusion criteria
* Patients treated with H2-receptor antagonist, PPI, bismuth and antibioticsin the previous 4 weeks. * Patients with gastrectomy, acute GI bleeding and advanced gastric cancer. * Patients with known or suspected allergy to study medications. * Currently pregnant or lactating. * Inability to provide informed consent and other situations that couldinterfere with the examination or therapeutic protocol.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The most suitable re-eradication time | 12 months | The most suitable re-eradication time#The unit is month# will be assessed by paired comparison method . |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Eradication rates in three groups | 12 months | Both intention to treat(ITT) and per-protocol(PP) analyses will be used for the assessment of the eradication rates of Helicobacter pylori infections in three groups |
Outcome results
None listed