Metabolic Disturbance
Conditions
Keywords
women, glycemic control, exercise
Brief summary
This study will determine how different at-home exercise strategies influence 24hr glycemic control in women with metabolic dysfunction.
Detailed description
Elevations in blood glucose concentration increase risk for cardiometabolic diseases including type 2 diabetes and cardiovascular diseases. Exercise can improve glycemic control, but there is limited research comparing the effectiveness of different exercise strategies in women. The aim of this study is to examine, under free-living conditions, how performing either walking and bodyweight interval exercise after dinner influences glycemic control in women with or at risk for type 2 diabetes. Glycemic control will be measured with continuous glucose monitors.
Interventions
BEHAVIORALBodyweight interval exercise
Performing 15 minutes of bodyweight interval exercise after dinner at home by following a video
BEHAVIORALWalking
Performing a 30 minute minute walk after dinner at home
Sponsors
University of Toronto
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
50 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Females * no cancer history * ≥50 years old * Have metabolic dysfunction (defined as self-reported diagnosis of pre-diabetes, type 2 diabetes, or at least moderate Canadian diabetes risk (CANRISK) score) * Owns a smartphone with Bluetooth capability with Apple or Android operating system * deemed safe to exercise as per the CSEP Get Active Questionnaire * Enrolled in NCT05454943
Exclusion criteria
* Type 1 diabetes * Taking exogenous insulin, sulfonylureas, or GLP-1 receptor agonists * Self-reported history of an eating disorder * BMI \<18.5 kg/m * Working night or rotating shifts * Eating window \<12 hours or consistently eating less than 3 meals/day in the past 3 months * Major dietary changes within the past 3 months (i.e. calorie counting, ketogenic diet)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 24hr Glucose area under the curve | 24 hours | Glucose area under the curve over 24hr |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postprandial dinner glucose response | 2 hours | Measured as the 2hr postprandial glucose incremental area under the curve (iAUC), average glucose and peak glucose |
| Postprandial breakfast glucose response | 2 hours | Measured as the 2hr postprandial iAUC, average glucose and peak glucose |
| Postprandial lunch glucose response | 2 hours | Measured as the 2hr postprandial glucose iAUC, average glucose and peak glucose |
| Nocturnal glucose | ~6-8 hours | Measured as the overnight glucose average and AUC |
| Time in hyperglycemia | 24 hours | Time (minutes and percent per day) above 10mmol/L over 24hr |
| Time in hypoglycemia | 24 hours | Time (minutes and percent per day) under 3.9mmol/L over 24 hr |
| 24hr Average glucose concentration | 24 hours | Average glucose concentration over 24 hr |
| Continuous overall net glycemic action (CONGA) | 24 hours | Calculated measure of glycemic variability |
| Change in glucose during exercise | 15-30 minutes | Post vs. pre glucose concentration around exercise |
| Mean amplitude glycemic excursion (MAGE) | 24 hours | Calculated measure of glycemic variability |
| Standard deviation (SD) | 24 hours | Calculated measure of glycemic variability |
| % coefficient of variation (CV) | 24 hours | Calculated measure of glycemic variability |
| Time in range | 24 hours | Time (minutes and percent per day) above 3.9 but under 10mmol/L |
Countries
Canada
Outcome results
None listed