COVID-19 Virus Infection, Fertility Disorders, Ovarian Function Insufficiency, Vaccine Adverse Reaction
Conditions
Keywords
ovarian reserve, covid-19, vaccine
Brief summary
Women's ovarian reserve and fertility were compared before and after 2 doses of vaccination
Detailed description
our study ıs desıgned as an observatıonal clınıcal study. the purpose ıs to compare the over reserve tests of the patıents before and after vaccıne, to determıne ıf the over reserve and fertılıty of women are affected by the vaccıne.women who applied to the vaccination outpatient clinic for the first dose of vaccine were included in the study.those who have never been vaccinated and have not had covid 19 infection were included in the study.antı ullerıan hormone level ıs the laboratory parameters that best showıng the ovary reserve today. ovarian reserve tests including amh were checked and their fertility was questioned and their information was recorded. the same tests were repeated after the volunteers received 2 doses of vaccine. ın the power analysis, it was calculated that 104 volunteers should be included in the study.the study will be terminated when 104 volunteers are reached.
Interventions
BIOLOGICALsars cov 2 biontec vaccine
volunteers will be expected to receive 2 doses of vaccine
Sponsors
Gaziosmanpasa Research and Education Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* between 18-45 years old * have ever had a covid vaccine * not be infected with covid 19
Exclusion criteria
* pregnancy * diagnosis of any kind of cancer * oral contraceptive usage * endometrioma * PCOS * menopause * menstrual irregularity * premature ovarian insufficiency
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ovarian reserve tests and fertility status of 74 women before and after vaccination | 6 months after receiving the 2nd dose of vaccine | before and after vaccination serum Amh level ng/ml |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| AMH difference between vaccinated and unvaccinated groups | 6 months | AMH difference between vaccinated and unvaccinated groups |
Countries
Turkey (Türkiye)
Outcome results
None listed