Insulin and Standard Management in Hypertriglyceridemic Acute Pancreatitis

Comparison of Insulin and Standard Management in Hypertriglyceridemic Acute Pancreatitis in Patients Without Diabetes

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05487833

Enrollment

Registered

2022-08-04

Start date

2022-11-30

Completion date

2024-09-30

Last updated

2022-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Pancreatitis, Hypertriglyceridemia

Brief summary

To compare the efficacy of infusion containing insulin and infusion without insulin on reduction of triglycerides in acute hypertriglyceridemic pancreatitis

Interventions

BIOLOGICALinsulin

5% glucose in 0.9% NaCl with 4 IU of short acting insulin per 500 ml added, infused at a rate determined by the treating physician, treatment duration: 18 hours

OTHERstandard treatment

infusion of a balanced solution, infused at a rate determined by the treating physician, treatment duration: 18 hours

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* acute pancreatitis * triglycerides \> 15 mmol/l

Exclusion criteria

* diabetes on peroral therapy or insulin * blood glucose \> 11 mmol/l * pregnancy

Design outcomes

Primary

Measure	Time frame	Description
%triglyceride reduction	after 18 hours of treatment	change in triglycerides, expressed as % of initial value

Secondary

Measure	Time frame
incidence of hypoglycemia	during treatment with insulin, up to day 5

Contacts

Primary ContactSamo Plut, MD

samo.plut@kclj.si00386 1 522 4165

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026