Gestational Diabetes Mellitus in Pregnancy
Conditions
Keywords
gestational diabetes mellitus, first trimester, prediction model
Brief summary
The aim of this study is to explore the diagnostic efficacy of oral glucose tolerance test in early pregnancy and establish the prediction model for gestational diabetes mellitus, so as to provide the optimal screening of gestational diabetes mellitus in the first trimester. The treatment started when the pregnancy was confirmed by transvaginal ultrasound (around 6 weeks of gestation) and continued until 42 days postpartum. The study is a single center, prospective cohort study. A total of 781 participants within 14 weeks of gestation were recruited.
Interventions
OTHERhyperglycemia exposure in the first trimester
The exposure means the hyperglycemia identified by the 75g oral glucose tolerance test before the 14 weeks of gestation
Sponsors
Women's Hospital School Of Medicine Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 45 Years
Inclusion criteria
* 1\. Intrauterine pregnancy within 7-14 weeks of gestation * 2\. 20-45 years of age * 3\. Singleton pregnancy * 4\. Giving informed consent and willing to participate in this study * 5\. Planning to give birth in Women's Hospital School of Medicine Zhejiang University
Exclusion criteria
* 1\. Pre-existing diabetes * 2\. Taking medications that may affect blood glucose levels within one month * 3\. Participating in other intervention studies * 4\. Recurrent abortion, threatened abortion, cervical incompetence or fetal malformation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| gestational diabetes mellitus | 24-28 weeks of gestation | any of the fasting, 1-hour and 2-hour blood glucose ≥ 5.1, 10.0, 8.5 mmol/L, respectively, in the 75g oral glucose tolerance test during 24-28 weeks of gestation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| gestational weight gain | before delivery | total weight gain from pre-pregnancy until delivery |
| gestational age at delivery | through study completion, an average of 39 gestational weeks | gestational weeks at the day of delivery |
| birthweight | within 24 hours after birth | birthweight of the infant |
| neonatal weight, height and head circumference | 42 days after birth | baby's weight, height and head circumference at 42 days after birth |
Countries
China
Outcome results
None listed